Exosomes: Emerging modulators of signal transduction in colorectal cancer from molecular understanding to clinical application

被引：26

作者：

Bahrami, Afsane ^{[1
]}

Binabaj, Maryam Moradi ^{[2
]}

Ferns, Gordon A. ^{[3
]}

机构：

[1] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[2] Sabzevar Univ Med Sci, Noncommunicable Dis Res Ctr, Sabzevar, Iran

[3] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, E Sussex, England

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 141卷

关键词：

Extracellular vesicles; Tumors; LncRNAs; MicroRNA; NE-kappa B; BETA-CATENIN; EXTRACELLULAR VESICLES; TUMOR MICROENVIRONMENT; PROTEOMIC ANALYSIS; MESSENGER-RNAS; BRAF MUTATIONS; CELLS; PATHWAY; PROTEIN; EXPRESSION;

D O I：

10.1016/j.biopha.2021.111882

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Exosomes are small cell derived membrane nano-vesicles that carry various components including lipids, proteins and nucleic acids. There is accumulating evidence that exosomes have a role in tumorigenesis, tumor invasiveness and metastasis. Furthermore, oncogene mutation may influence exosome release from tumor cells. Exosomes may induce colorectal cancer by altering signaling cascades such as the Wnt/beta-catenin and KRAS pathways that are involved in cell proliferation, apoptosis, dissemination, angiogenesis, and drug resistance. The aim of this review was to overview recent findings evaluating the association between tumor cells-derived exosomes and their content in modulating signaling pathways in colorectal cancer.

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页数：10

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