Exosomes: Emerging modulators of signal transduction in colorectal cancer from molecular understanding to clinical application

被引：26

作者：

Bahrami, Afsane ^{[1
]}

Binabaj, Maryam Moradi ^{[2
]}

Ferns, Gordon A. ^{[3
]}

机构：

[1] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[2] Sabzevar Univ Med Sci, Noncommunicable Dis Res Ctr, Sabzevar, Iran

[3] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, E Sussex, England

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 141卷

关键词：

Extracellular vesicles; Tumors; LncRNAs; MicroRNA; NE-kappa B; BETA-CATENIN; EXTRACELLULAR VESICLES; TUMOR MICROENVIRONMENT; PROTEOMIC ANALYSIS; MESSENGER-RNAS; BRAF MUTATIONS; CELLS; PATHWAY; PROTEIN; EXPRESSION;

D O I：

10.1016/j.biopha.2021.111882

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Exosomes are small cell derived membrane nano-vesicles that carry various components including lipids, proteins and nucleic acids. There is accumulating evidence that exosomes have a role in tumorigenesis, tumor invasiveness and metastasis. Furthermore, oncogene mutation may influence exosome release from tumor cells. Exosomes may induce colorectal cancer by altering signaling cascades such as the Wnt/beta-catenin and KRAS pathways that are involved in cell proliferation, apoptosis, dissemination, angiogenesis, and drug resistance. The aim of this review was to overview recent findings evaluating the association between tumor cells-derived exosomes and their content in modulating signaling pathways in colorectal cancer.

引用

收藏

页数：10

相关论文

共 155 条

[31]

KRAS-dependent sorting of miRNA to exosomes [J].

Cha, Diana J. ;

Franklin, Jeffrey L. ;

Dou, Yongchao ;

Liu, Qi ;

Higginbotham, James N. ;

Beckler, Michelle Demory ;

Weaver, Alissa M. ;

Vickers, Kasey ;

Prasad, Nirpesh ;

Levy, Shawn ;

Zhang, Bing ;

Coffey, Robert J. ;

Patton, James G. .

ELIFE, 2015, 4 :22

[32]

MIR-27a regulates the TGF- signaling pathway by targeting SMAD2 and SMAD4 in lung cancer [J].

Chae, Dong-Kyu ;

Ban, Eunmi ;

Yoo, Young Sook ;

Kim, Eunice EunKyeong ;

Baik, Ja-Hyun ;

Song, Eun Joo .

MOLECULAR CARCINOGENESIS, 2017, 56 (08) :1992-1998

[33]

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling [J].

Chairoungdua, Arthit ;

Smith, Danielle L. ;

Pochard, Pierre ;

Hull, Michael ;

Caplan, Michael J. .

JOURNAL OF CELL BIOLOGY, 2010, 190 (06) :1079-1091

[34]

Distinct shed microvesicle and exosome microRNA signatures reveal diagnostic markers for colorectal cancer [J].

Chen, Maoshan ;

Xu, Rong ;

Rai, Alin ;

Suwakulsiri, Wittaya ;

Izumikawa, Keiichi ;

Ishikawa, Hideaki ;

Greening, David W. ;

Takahashi, Nobuhiro ;

Simpson, Richard J. .

PLOS ONE, 2019, 14 (01)

[35]

Protein content and functional characteristics of serum-purified exosomes from patients with colorectal cancer revealed by quantitative proteomics [J].

Chen, Yanyu ;

Xie, Yong ;

Xu, Lai ;

Zhan, Shaohua ;

Xiao, Yi ;

Gao, Yanpan ;

Wu, Bin ;

Ge, Wei .

INTERNATIONAL JOURNAL OF CANCER, 2017, 140 (04) :900-913

[36]

Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines [J].

Chiba, Mitsuru ;

Kimura, Misako ;

Asari, Saya .

ONCOLOGY REPORTS, 2012, 28 (05) :1551-1558

[37]

Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells [J].

Choi, Dong-Sic ;

Choi, Do-Young ;

Hong, Bok Sil ;

Jang, Su Chul ;

Kim, Dae-Kyum ;

Lee, Jaewook ;

Kim, Yoon-Keun ;

Kim, Kwang Pyo ;

Gho, Yong Song .

JOURNAL OF EXTRACELLULAR VESICLES, 2012, 1 (01)

[38]

Proteomic analysis of microvesicles derived from human colorectal cancer ascites [J].

Choi, Dong-Sic ;

Park, Jung Ok ;

Jang, Su Chul ;

Yoon, Yae Jin ;

Jung, Jin Woo ;

Choi, Do-Young ;

Kim, Jung-Wook ;

Kang, Ji Seon ;

Park, Jaesung ;

Hwang, Daehee ;

Lee, Kyung-Hee ;

Park, Sang-Hyun ;

Kim, Yoon-Keun ;

Desiderio, Dominic M. ;

Kim, Kwang Pyo ;

Gho, Yong Song .

PROTEOMICS, 2011, 11 (13) :2745-2751

[39]

The Wnt pathway and the roles for its antagonists, DKKS, in angiogenesis [J].

Choi, Hyun-Jung ;

Park, Hongryeol ;

Lee, Heon-Woo ;

Kwon, Young-Guen .

IUBMB LIFE, 2012, 64 (09) :724-731

[40]

Autoregulation of E-cadherin expression by cadherin-cadherin interactions:: the roles of β-catenin signaling, Slug, and MAPK [J].

Conacci-Sorrell, M ;

Simcha, I ;

Ben-Yedidia, T ;

Blechman, J ;

Savagner, P ;

Ben-Ze'ev, A .

JOURNAL OF CELL BIOLOGY, 2003, 163 (04) :847-857

← 1 2 3 4 5 6 7 8 9 10 →