Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy

被引:70
作者
MacLennan, J [1 ]
Obaro, S
Deeks, J
Lake, D
Elie, C
Carlone, G
Moxon, ER
Greenwood, B
机构
[1] John Radcliffe Hosp, Dept Pediat, Oxford Vaccine Grp, Oxford OX3 9DU, England
[2] Ctr Stat Med, Oxford, England
[3] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England
[4] MRC Labs, Banjul, Gambia
[5] Ctr Dis Control & Prevent, Atlanta, GA USA
基金
英国医学研究理事会;
关键词
D O I
10.1086/317667
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Infant vaccination with meningococcal conjugates may provide long-term protection against disease. Antibody levels and immunologic memory were assessed in 5-year-old Gambian children who received meningococcal A/C conjugate vaccination (MenA/C) in infancy. At 2 years, they were randomized to receive a booster of MenA/C (conjugate group), meningococcal A/C polysaccharide (MPS group), or inactivated polio vaccine (IPV group). All groups were revaccinated with 10 mug MPS at 5 years of age, as were 39 previously unvaccinated age-matched control subjects. Before revaccination, titers were higher in the conjugate and MPS groups than in control subjects (P<.001); titers for the IPV group were similar to those for control subjects. Ten days after revaccination, the conjugate and IPV groups had similar serogroup C serum bactericidal antibody titers (3421 vs. 2790, respectively). These levels were significantly higher than those in the MPS (426) and control (485) groups (P<.001). Thus, immunologic memory was sustained for greater than or equal to5 years; however, MPS challenge at 2 years interfered with a subsequent memory response.
引用
收藏
页码:97 / 104
页数:8
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