Roles for TGF-β and Programmed Cell Death 1 Ligand 1 in Regulatory T Cell Expansion and Diabetes Suppression by Zymosan in Nonobese Diabetic Mice

被引：24

作者：

Burton, Oliver T. ^{[1
]}

Zaccone, Paola ^{[1
]}

Phillips, Jenny M. ^{[1
]}

De La Pena, Hugo ^{[1
,2
]}

Fehervari, Zoltan ^{[1
]}

Azuma, Miyuki ^{[3
]}

Gibbs, Sarah ^{[1
]}

Stockinger, Brigitta ^{[2
]}

Cooke, Anne ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

[2] Natl Inst Med Res, MRC, Dept Mol Immunol, London NW7 1AA, England

[3] Tokyo Med & Dent Univ, Dept Mol Immunol, Tokyo, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 05期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

PLASMACYTOID DENDRITIC CELLS; ANTIGEN-PRESENTING CELLS; NOD MICE; EXTRACELLULAR-MATRIX; RECEPTOR DECTIN-1; CANDIDA-ALBICANS; B-LYMPHOCYTES; IN-VIVO; INDUCTION; PREVENTS;

D O I：

10.4049/jimmunol.1001365

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zymosan is a complex fungal component shown to be capable of both promoting and suppressing the development of autoimmune disorders in mice. In this study, we show that a single injection of zymosan just prior to diabetes onset can significantly delay the progression of disease in NOD mice. Zymosan treatment of NOD mice induced the production of biologically active TGF-beta from cells infiltrating the pancreas and was associated with expansion of programmed cell death 1 ligand 1(+)TGF-beta(+) macrophages and Foxp3(+) regulatory T cells in vivo. Neutralization of either TGF-beta or programmed cell death 1 ligand 1 abrogated the protective effects of zymosan. Zymosan acted through TLR2 as well as ERK and p38 MAPK to induce macrophage secretion of TGF-beta and promotion of Foxp3(+) regulatory T cells in vitro and in vivo. The Journal of Immunology, 2010, 185: 2754-2762.

引用

页码：2754 / 2762

页数：9

共 71 条

[21] Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion [J].

Goudy, KS ;

Burkhardt, BR ;

Wasserfall, C ;

Song, SH ;

Campbell-Thompson, ML ;

Brusko, T ;

Powers, MA ;

Clare-Salzler, MJ ;

Sobel, ES ;

Ellis, TM ;

Flotte, TR ;

Atkinson, MA .

JOURNAL OF IMMUNOLOGY, 2003, 171 (05) :2270-2278

[22] CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes [J].

Green, EA ;

Gorelik, L ;

McGregor, CM ;

Tran, EH ;

Flavell, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10878-10883

[23] Expression of transgene encoded TGF-β in islets prevents autoimmune diabetes in NOD mice by a local mechanism [J].

Grewal, IS ;

Grewal, KD ;

Wong, FS ;

Wang, H ;

Picarella, DE ;

Janeway, CA ;

Flavell, RA .

JOURNAL OF AUTOIMMUNITY, 2002, 19 (1-2) :9-22

[24] Mechanisms of PDL-1 mediated regulation of autoimmune diabetes [J].

Guleria, Indira ;

Bupp, Melanie Gubbels ;

Dada, Shirine ;

Fife, Brian ;

Tang, Qizhi ;

Ansari, Mohammed Javeed ;

Trikudanathan, Subbulaxmi ;

Vadivel, Nidyanandh ;

Fiorina, Paolo ;

Yagita, Hideo ;

Azuma, Miyuki ;

Atkinson, Mark ;

Bluestone, Jeffrey A. ;

Sayegh, Mohamed H. .

CLINICAL IMMUNOLOGY, 2007, 125 (01) :16-25

[25] Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes [J].

Höglund, P ;

Mintern, J ;

Waltzinger, C ;

Heath, W ;

Benoist, C ;

Mathis, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (02) :331-339

[26] TRANSFER OF DIABETES IN MICE PREVENTED BY BLOCKADE OF ADHESION-PROMOTING RECEPTOR ON MACROPHAGES [J].

HUTCHINGS, P ;

ROSEN, H ;

OREILLY, L ;

SIMPSON, E ;

GORDON, S ;

COOKE, A .

NATURE, 1990, 348 (6302) :639-641

[27] The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice [J].

Jun, HS ;

Yoon, CS ;

Zbytnuik, L ;

van Rooijen, N ;

Yoon, JW .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (02) :347-358

[28] Human CD14+ Macrophages in Intestinal Lamina Propria Exhibit Potent Antigen-Presenting Ability [J].

Kamada, Nobuhiko ;

Hisamatsu, Tadakazu ;

Honda, Haruki ;

Kobayashi, Taku ;

Chinen, Hiroshi ;

Kitazume, Mina Tokutake ;

Takayama, Tetsuro ;

Okamoto, Susumu ;

Koganei, Kazutaka ;

Sugita, Akira ;

Kanai, Takanori ;

Hibi, Toshifumi .

JOURNAL OF IMMUNOLOGY, 2009, 183 (03) :1724-1731

[29] Macrophage deletion of p38α partially impairs lipopolysaccharide-induced cellular activation [J].

Kang, Young Jun ;

Chen, Jianming ;

Otsuka, Motoyuki ;

Mols, Johann ;

Ren, Shuxun ;

Wang, Yinbin ;

Han, Jiahuai .

JOURNAL OF IMMUNOLOGY, 2008, 180 (07) :5075-5082

[30] Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4+CD25+ regulatory T-cells [J].

Kared, H ;

Masson, A ;

Adle-Biassette, H ;

Bach, JF ;

Chatenoud, L ;

Zavala, F .

DIABETES, 2005, 54 (01) :78-84

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