Polymer microcapsules as mobile local pH-sensors

被引：210

作者：

Kreft, Oliver

Javier, Almudena Munoz

Sukhorukov, Gleb B.

Parak, Wolfgang J. ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interface, Potsdam, Germany

[2] Univ Munich, Ctr Nanosci, Munich, Germany

[3] Univ London Queen Mary, Dept Mat, London E1 4NS, England

[4] Univ Marburg, Fachbereich Phys, Marburg, Germany

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2007年 / 17卷 / 42期

关键词：

D O I：

10.1039/b705419j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Polyelectrolyte microcapsules have been loaded with a pH- sensitive, high molecular weight SNARF-1-dextran conjugate. SNARF-1 exhibits a significant pH-dependent emission shift from green to red fluorescence under acidic and basic conditions, respectively. The unique spectral properties of the dye were maintained after the encapsulation. By investigating both human breast cancer cells and fibroblasts, we were able to follow the pH change of the local environment of SNARF-1-filled capsules during the transition from the alkaline cell medium to the acidic endosomal/lysosomal compartments. The incorporation of magnetite nanoparticles and an additional pH-insensitive fluorophore within the capsule shell resulted in a novel type of sensor system based on multifunctional polymer capsules.

引用

收藏

页码：4471 / 4476

页数：6

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