Complete coding sequences of dengue-1 viruses from Paraguay and Argentina

被引：11

作者：

Avilés, G ^{[1
]}

Meissner, J ^{[1
]}

Mantovani, R ^{[1
]}

St Jeor, S ^{[1
]}

机构：

[1] Univ Nevada, Dept Microbiol, Reno, NV 89557 USA

来源：

VIRUS RESEARCH | 2003年 / 98卷 / 01期

关键词：

dengue-1; South America; coding sequences; quasispecies;

D O I：

10.1016/j.virusres.2003.08.018

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have determined the complete coding sequences of six dengue-1 (DEN-1) viruses isolated from Paraguay and Argentina in 2000 from patients with dengue fever. Sequences of strains 259par00, 280par00, 295arg00, 297arg00 and 301 arg00 can encode a polyprotein of 3392 amino acids. Strain 293arg00 circulated as a "wild type + deletion mutant" quasispecies, with a subpopulation characterized by a 3-nucleotide deletion in the NS4A region. This variant, which would encode a three amino acid change in the NS4A protein, was found as a minority population in one additional partially-sequenced isolate from the same outbreak. These six South American strains group into two different clades of the "American-African" DEN-1 genotype-one clade is most closely related to strains isolated from Brazil in 1997, the other to a Peruvian strain isolated in 1991 for which only partial sequence information is available. DEN-1 viruses isolated worldwide comprise at least four different genotypes according to previously defined classification criteria. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：75 / 82

页数：8

共 28 条

[1]

Avilés G, 2003, EMERG INFECT DIS, V9, P738

[2] Phylogenetic relationships of dengue-1 viruses from Argentina and Paraguay [J].