Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering

被引：531

作者：

Swetha, Maddela ^{[1
]}

Sahithi, Kolli ^{[1
]}

Moorthi, Ambigapathi ^{[1
]}

Srinivasan, Narasimhan ^{[2
]}

Ramasamy, Kumarasamy ^{[1
]}

Selvamurugan, Nagarajan ^{[1
,2
]}

机构：

[1] SRM Univ, Dept Biotechnol, Sch Bioengn, Kattankulathur 603203, Tamil Nadu, India

[2] Univ Madras Taramani, Dept Endocrinol, Dr ALM Post Grad Inst Basic Med Sci, Chennai 600113, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 47卷 / 01期

关键词：

Chitosan; Collagen; Hydroxyapatite; Nano materials; Biocomposites; Bone; COMPOSITE SCAFFOLDS; BIODEGRADABLE POLYMERS; NANO-HYDROXYAPATITE; PROTEIN ADSORPTION; IN-SITU; MEMBRANES; MINERALIZATION; NANOPARTICLES; EXPRESSION; NANOFIBERS;

D O I：

10.1016/j.ijbiomac.2010.03.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Bone tissue engineering is an alternative strategy to generate bone utilizing a combination of biomaterials and cells. Biomaterials that mimic the structure and composition of bone tissues at nanoscale are important for the development of bone tissue engineering applications. Natural or biopolymer-based composites containing chitin, chitosan, or collagen have advantages such as biocompatibility, biodegradability that are essential for bone tissue engineering. The inclusion of nanoparticles of hydroxyapatite (one of the most widely used bioceramic materials) into the biopolymer matrix improves the mechanical properties and incorporates the nanotopographic features that mimic the nanostructure of bone. This review summarizes the recent work on the development of biocomposites containing natural polymers with hydroxyapatite particles suitable for use in bone defects/bone regeneration. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1 / 4

页数：4

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