Copper(II) tetrafluoroborate as a novel and highly efficient catalyst for Michael addition of mercaptans to α,β-unsaturated carbonyl compounds

被引：121

作者：

Garg, SK ^{[1
]}

Kumar, R ^{[1
]}

Chakraborti, AK ^{[1
]}

机构：

[1] NIPER, Dept Med Chem, Nagar 160062, Punjab, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 10期

关键词：

Michael addition; thiol; alpha; beta-unsaturated carbonyl; copper(II) tetrafluoroborate; catalyst;

D O I：

10.1016/j.tetlet.2005.01.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper(II) tetrafluoroborate has been found to be a new and highly efficient catalyst for Michael addition of thiols to alpha,beta-unsaturated carbonyl compounds under solvent-free conditions and in H2O at room temperature. The reactions are very fast and are completed in 2 min to 1 h affording high yields. The rate of thiol addition was dependent on the steric hindrance at the beta-carbon of the alpha,beta-unsaturated carbonyl substrate. In the case of chalcones, the reactions are best carried out in MeOH as solvent. (C) 2005 Elsevier Ltd. All rights reserved.

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页码：1721 / 1724

页数：4

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