Genomic strategies for diabetic nephropathy

被引:28
作者
Susztak, K
Sharma, K
Schiffer, M
McCue, P
Ciccone, E
Böttinger, EP
机构
[1] Albert Einstein Coll Med, Dept Med, Div Nephrol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA
[3] Thomas Jefferson Univ, Dept Med, Div Nephrol, Philadelphia, PA 19107 USA
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2003年 / 14卷
关键词
D O I
10.1097/01.ASN.0000078035.81397.8A
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Insight into the molecular mechanisms that underlie the origin and progression of diabetic nephropathy remains limited in part because conventional research tools have restricted investigators to focus on single genes or isolated pathways. Microarray technologies provide opportunities for evaluating genetic factors and environmental effects at a genomic scale during the pathogenesis of diabetic nephropathy. Despite the enormous power of the microarray technology, there are several pitfalls that need to be considered. This article discusses conceptual, practical, statistical, and logistical considerations for the use of microarrays in studies of experimental and human diabetic renal disease. New knowledge in this field will facilitate new approaches for molecular diagnosis and drug discovery.
引用
收藏
页码:S271 / S278
页数:8
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