Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains

被引：158

作者：

Deidda, D

Lampis, G

Fioravanti, R

Biava, M

Porretta, GC

Zanetti, S

Pompei, R

机构：

[1] Univ Cagliari, Cattedra Microbiol Applicata, Dipartimento Sci Med, I-09124 Cagliari, Italy

[2] Univ Rome La Sapienza, Dipartimento Studi Chim TSBA, Rome, Italy

[3] Univ Sassari, Ist Microbiol, I-07100 Sassari, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 11期

关键词：

D O I：

10.1128/AAC.42.11.3035

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pyrrole derivative BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl) methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis mycobacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.

引用

页码：3035 / 3037

页数：3