Diminished cortisol responses to psychosocial stress associated with lifetime adverse events - A study among healthy young subjects

被引:276
作者
Elzinga, Bernet M. [1 ]
Roelofs, Karin [1 ]
Tollenaar, Marieke S. [1 ]
Bakvis, Patricia [1 ,2 ]
van Pelt, Johannes [3 ]
Spinhoven, Philip [1 ]
机构
[1] Leiden Univ, Dept Clin Hlth & Neuropsychol, NL-2333 AK Leiden, Netherlands
[2] SEIN, Heemstede, Netherlands
[3] LUMC, Dept Clin Chem, Leiden, Netherlands
关键词
HPA axis; cortisol; trauma; psychosocial stress; resilience; stress inoculation;
D O I
10.1016/j.psyneuen.2007.11.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Animal and human studies have found that prior stressful events can result in an altered reactivity in the HPA axis. The aim of the present study was to investigate the role of adverse events in childhood on cortisol reactivity to psychosocial stress in young healthy subjects (n = 80). Methods: Salivary cortisol levels were measured before, during and after exposure to a psychosocial stress task in healthy men and women with high (n = 33) and tow (n = 47) exposure to adverse childhood events. Results: A significant blunted cortisol response was found in individuals with a history of adverse events compared to individuals with no adverse life events, with no differences in baseline cortisol levels. This finding appeared to be primarily driven by men. The groups did not differ on any other physiological or subjective stress measure, including heart rate, blood pressure, and subjective tension. Conclusions: These findings suggest that, at least in healthy young mates, adverse childhood events are associated with changes in HPA-axis functioning. Longitudinal studies are needed to investigate whether the blunted cortisol response is a risk factor in the etiology of psychiatric disorders or rather reflects resiliency with regard to the development of psychopathology. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:227 / 237
页数:11
相关论文
共 66 条
[41]   Relationships between self-reported potentially traumatizing events, psychoform and somatoform dissociation, and absorption, in two non-clinical populations [J].
Näring, G ;
Nijenhuis, ERS .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2005, 39 (11-12) :982-988
[42]   The psychometric characteristics of the Traumatic Experiences Checklist (TEC): First findings among psychiatric outpatients [J].
Nijenhuis, ERS ;
Van der Hart, O ;
Kruger, K .
CLINICAL PSYCHOLOGY & PSYCHOTHERAPY, 2002, 9 (03) :200-210
[43]   Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates [J].
Parker, KJ ;
Buckmaster, CL ;
Sundlass, K ;
Schatzberg, AF ;
Lyons, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :3000-3005
[44]   Prospective investigation of stress inoculation in young monkeys [J].
Parker, KJ ;
Buckmaster, CL ;
Schatzberg, AF ;
Lyons, DM .
ARCHIVES OF GENERAL PSYCHIATRY, 2004, 61 (09) :933-941
[45]   EARLY, POSTNATAL EXPERIENCE ALTERS HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR (CRF) MESSENGER-RNA, MEDIAN-EMINENCE CRF CONTENT AND STRESS-INDUCED RELEASE IN ADULT-RATS [J].
PLOTSKY, PM ;
MEANEY, MJ .
MOLECULAR BRAIN RESEARCH, 1993, 18 (03) :195-200
[46]  
PLOTSKY PM, 2005, J NEUROSCI, V3012, P2192
[47]   Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change [J].
Pruessner, JC ;
Kirschbaum, C ;
Meinlschmid, G ;
Hellhammer, DH .
PSYCHONEUROENDOCRINOLOGY, 2003, 28 (07) :916-931
[48]  
RESNICK HS, 1995, AM J PSYCHIAT, V152, P1675
[49]   The effects of social stress and cortisol responses on the preconscious selective attention to social threat [J].
Roelofs, Karin ;
Bakvis, Patricia ;
Hermans, Erno J. ;
van Pelt, Johannes ;
van Honk, Jack .
BIOLOGICAL PSYCHOLOGY, 2007, 75 (01) :1-7
[50]   LIFE CHANGE AND RAPE IMPACT [J].
RUCH, LO ;
CHANDLER, SM ;
HARTER, RA .
JOURNAL OF HEALTH AND SOCIAL BEHAVIOR, 1980, 21 (03) :248-260