Activated THP-1 cells:: An attractive model for the assessment of intracellular growth rates of Mycobacterium tuberculosis isolates

被引：80

作者：

Theus, SA

Cave, MD

Eisenach, KD

机构：

[1] Univ Arkansas Med Sci, Cent Arkansas Vet Healthcare Syst, Med Res Serv, Dept Pathol, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Dept Immunol Microbiol, Little Rock, AR 72205 USA

[3] Univ Arkansas Med Sci, Dept Anat, Little Rock, AR 72205 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 02期

关键词：

D O I：

10.1128/IAI.72.2.1169-1173.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Capacity of certain Mycobacterium tuberculosis isolates to grow more rapidly in human macrophages may be indicative of increased virulence. Significant differences were observed in intracellular growth of two isolates from sites of tuberculosis transmission, with an outbreak-associated strain growing faster than a strain causing disease in only one person. Activated THP-1 cells are a suitable alternative to peripheral blood monocyte models.

引用

页码：1169 / 1173

页数：5

共 11 条

[1] Tuberculosis transmission in central Los Angeles [J].

Barnes, PF ;

Yang, ZH ;

PrestonMartin, S ;

Pogoda, JM ;

Jones, BE ;

Otaya, M ;

Eisenach, KD ;

Knowles, L ;

Harvey, S ;

Cave, MD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (14) :1159-1163

[2] Differences in rate and variability of intracellular growth of a panel of Mycobacterium tuberculosis clinical isolates within a human monocyte model [J].

Li, Q ;

Whalen, CC ;

Albert, JM ;

Larkin, R ;

Zukowski, L ;

Cave, MD ;

Silver, RF .

INFECTION AND IMMUNITY, 2002, 70 (11) :6489-6493

[3]

Manca C, 1999, J IMMUNOL, V162, P6740

[4] DRUG-RESISTANT STRAINS OF MYCOBACTERIUM-TUBERCULOSIS EXHIBIT A RANGE OF VIRULENCE FOR MICE [J].

ORDWAY, DJ ;

SONNENBERG, MG ;

DONAHUE, SA ;

BELISLE, JT ;

ORME, IM .

INFECTION AND IMMUNITY, 1995, 63 (02) :741-743

[5] Comparable growth of virulent and avirulent Mycobacterium tuberculosis in human macrophages in vitro [J].

Paul, S ;

Laochumroonvorapong, P ;

Kaplan, G .

JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (01) :105-112

[6] THP-1 cell apoptosis in response to mycobacterial infection [J].

Riendeau, CJ ;

Kornfeld, H .

INFECTION AND IMMUNITY, 2003, 71 (01) :254-259

[7] The receptor-mediated uptake, survival, replication, and drug sensitivity of Mycobacterium tuberculosis within the macrophage-like cell line THP-1:: A comparison with human monocyte-derived macrophages [J].

Stokes, RW ;

Doxsee, D .

CELLULAR IMMUNOLOGY, 1999, 197 (01) :1-9

[8] Establishment of an activated macrophage cell line, A-THP-1, and its properties [J].

Tominaga, T ;

Suzuki, M ;

Saeki, H ;

Matsuno, S ;

Tachibana, T ;

Kudo, T .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 186 (02) :99-119

[9] An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosis [J].

Valway, SE ;

Sanchez, MPC ;

Shinnick, TF ;

Orme, I ;

Agerton, T ;

Hoy, D ;

Jones, JS ;

Westmoreland, H ;

Onorato, IM .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (10) :633-639

[10] Enhanced capacity of a widespread strain of Mycobacterium tuberculosis to grow in human macrophages [J].

Zhang, M ;

Gong, JH ;

Yang, ZH ;

Samten, B ;

Cave, MD ;

Barnes, PF .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (05) :1213-1217

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