Does metformin protect against osteoarthritis? An electronic health record cohort study

被引：25

作者：

Barnett, Lauren A. ^{[1
]}

Jordan, Kelvin P. ^{[2
]}

Edwards, John J. ^{[1
]}

van der Windt, Danielle A. ^{[3
]}

机构：

[1] Keele Univ, Res Inst Primary Care & Hlth Sci, Arthrit Res UK Primary Care Ctr, Keele ST5 5BG, Staffs, England

[2] Keele Univ, Res Inst Primary Care & Hlth Sci, Biostat, Arthrit Res UK Primary Care Ctr, Keele, Staffs, England

[3] Keele Univ, Res Inst Primary Care & Hlth Sci, Arthrit Res UK Primary Care Ctr, Primary Care Epidemiol, Keele, Staffs, England

来源：

PRIMARY HEALTH CARE RESEARCH AND DEVELOPMENT | 2017年 / 18卷 / 06期

关键词：

cohort; osteoarthritis; survival analysis; IMPACT; CARE;

D O I：

10.1017/S1463423617000287

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Background: Obesity is a major risk factor for osteoarthritis (OA) whilst there is some evidence that diabetes also increases risk. Metformin is a common oral treatment for those with diabetes. Objective: The aim is to investigate whether metformin reduces the risk of OA. Methods: This was a cohort study set within the Consultations in Primary Care Archive, with 3217 patients with type 2 diabetes. Patients at 13 general practices with recorded type 2 diabetes in the baseline period (2002-2003) and no prior record of OA were identified. Exposure was a prescription for metformin. Outcome was an OA record during follow up. Cox proportional hazard models with Gamma frailty term were fitted: adjusted for age, gender, deprivation, and comorbidity. Results: There was no association between prescribed metformin treatment at baseline and OA (adjusted HR: 1.02, 95% CI: 0.91, 1.15). A similar non-significant association was found when allowing exposure status of prescription of metformin to vary over time.

引用

页码：623 / 628

页数：6

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