Protein structure prediction: Inroads to biology

被引：109

作者：

Petrey, D ^{[1
]}

Honig, B ^{[1
]}

机构：

[1] Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, Ctr Computat Biol & Bioinformat, New York, NY 10032 USA

来源：

MOLECULAR CELL | 2005年 / 20卷 / 06期

关键词：

D O I：

10.1016/j.molcel.2005.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, there has been significant progress in the ability to predict the three-dimensional structure of proteins from their amino acid sequence. Progress has been due to new methods to extract the growing amount of information in sequence and structure databases and improved computational descriptions of protein energetics. This review summarizes recent advances in these areas and describes a number of novel biological applications made possible by structure prediction. Despite remaining challenges, protein structure prediction is becoming an extremely useful tool in understanding phenomena in modern molecular and cell biology. Copyright ©2005 by Elsevier Inc.

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收藏

页码：811 / 819

页数：9

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