Estrogen receptor α mediates estrogen's immune protection in autoimmune disease

被引:113
作者
Liu, HB
Loo, KK
Palaszynski, K
Ashouri, J
Lubahn, DB
Voskuhl, RR
机构
[1] Univ Calif Los Angeles, Reed Neurol Res Ctr, Dept Neurol, Los Angeles, CA 90095 USA
[2] Univ Missouri, Dept Biochem Child Hlth & Anim Sci, Columbia, MO 65211 USA
关键词
D O I
10.4049/jimmunol.171.12.6936
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Estrogens are known to influence a variety of autoimmune diseases, but it is not known whether their actions are mediated through classic estrogen receptor alpha (ERalpha). The presence of a functional ER was demonstrated in secondary lymphoid tissues, then ERalpha expression was shown at both the RNA and protein levels in these tissues. Use of ERalpha knockout mice revealed that both the estrogen-induced disease protection and the estrogen-induced reduction in proinflammatory cytokines were dependent upon ERalpha in the prototypic Th1-mediated autoimmune disease experimental autoimmune encephalomyelitis. These findings are central to the design of selective ER modifiers which aim to target biologic responses in specific organ systems.
引用
收藏
页码:6936 / 6940
页数:5
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