The role of vitamin D in the immunopathogenesis of allergic skin diseases

被引：99

作者：

Benson, A. A.

Toh, J. A. ^{[2
]}

Vernon, N. ^{[3
]}

Jariwala, S. P. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Montefiore Med Ctr, Div Allergy Immunol, Bronx, NY 10463 USA

[2] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Med, Bronx, NY 10463 USA

[3] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Pediat, Bronx, NY 10463 USA

来源：

ALLERGY | 2012年 / 67卷 / 03期

关键词：

atopic dermatitis; environment; epidemiology; vitamin D; urticaria; 25-HYDROXYVITAMIN D LEVELS; D-RECEPTOR; ATOPIC-DERMATITIS; D SUPPLEMENTATION; PREGNANCY; ASTHMA; PRESCRIPTIONS; SEVERITY; WHEEZE; CELLS;

D O I：

10.1111/j.1398-9995.2011.02755.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Vitamin D plays key roles in innate and adaptive immunity through the stimulation of Toll-like receptors, increasing pro-inflammatory cytokine production, and possibly enhancing T helper type 2 responses. These mechanisms may explain the growing body of evidence connecting vitamin D to allergic diseases, including asthma, food allergies, and allergic rhinitis. The data relating vitamin D to allergic skin diseases are equivocal with studies linking both high and low vitamin D levels to an increased risk of developing atopic dermatitis. In this paper, we describe the role of vitamin D in the immunopathogenesis of atopic dermatitis and other allergic skin diseases.

引用

页码：296 / 301

页数：6

共 44 条

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