Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the Istituto Ortopedico Rizzoli according to the Istituto Ortopedico Rizzoli Osteosarcoma-2 protocol: An updated report

被引:320
作者
Bacci, G
Ferrari, S
Bertoni, F
Ruggieri, P
Picci, P
Longhi, A
Casadei, R
Fabbri, N
Forni, C
Versari, M
Campanacci, M
机构
[1] Ist Ortoped Rizzoli, IF Goidanich, Serv Chemotherapy, Sez Chemioterapia, I-40136 Bologna, Italy
[2] Ist Ortoped Rizzoli, IF Goidanich, Pathol Lab, I-40136 Bologna, Italy
[3] Ist Ortoped Rizzoli, IF Goidanich, Serv Orthoped Surg 5, I-40136 Bologna, Italy
[4] Ist Ortoped Rizzoli, IF Goidanich, Dept Musculoskeletal Oncol, Lab Oncol Res, I-40136 Bologna, Italy
关键词
D O I
10.1200/JCO.2000.18.24.4016
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To provide an estimate of long-term prognosis for patients with osteosarcoma of the extremity treated in a single institution with neoadjuvant chemotherapy and observed for at least 10 years. Patients and Methods: Patients with nonmetastatic osteosarcoma of the extremity were preoperatively treated with high-dose methotrexate, cisplatin, and doxorubicin (ADM). Postoperatively, good responders (90% Or more tumor necrosis) received the same three drugs-used before surgery, whereas poor responders (less than 90% tumor necrosis) received ifosfamide and etoposide in addition to those three drugs. Results: For the 164 patients who entered the study between September 1986 and December 1989, surgery was a limb salvage in 136 cases (82%) and a good histologic response was observed in 117 patients (71%). At a follow-up ranging from 10 to 13 years (median, 11.5 years), 101 patients (61%) remained continuously free of disease, 61 relapsed, and two died of ADM-induced cardiotoxicity. There were no differences in prognosis between good and poor responding patients. ADM-induced cardiotoxicity (six patients), male infertility (10 of the 12 assessable patients), and second malignancies (seven patients) were the major complications of chemotherapy. Despite the large number of limb salvages performed, only four local recurrences (2.4%) were registered. Conclusion: With an aggressive neoadjuvant chemotherapy, it is possible to cure more than 60% of patients with nonmetastatic osteosarcoma of the extremity and amputation may be avoided in more than 80% of them, Because local or systemic relapses, myocardiopathies, and second malignancies are possible even 5 years or more after the beginning of treatment, a long-term follow-up is recommended for these patients. J Clin Oncol 18:4016-4027. (C) 2000 by American Society of Clinical Oncology.
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页码:4016 / 4027
页数:12
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