Strategies for identification of HIV-1 integrase inhibitors

被引：4

作者：

Ramcharan, Joseph ^{[1
]}

Skalka, Anna Marie ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Inst Canc Res, Philadelphia, PA 19111 USA

来源：

FUTURE VIROLOGY | 2006年 / 1卷 / 06期

关键词：

antiretroviral therapy; concerted integration; diketo acids; high-throughput screening; host protein targets; integrase tetramer models; joining reaction; preintegration complex; processing reaction; Tn5 surrogate target;

D O I：

10.2217/17460794.1.6.717

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 integrase, which catalyzes the joining of viral DNA to the host cell DNA, has attracted considerable attention as a target for the design and screening of novel anti-HIV drugs as it is essential for virus replication and the establishment of persistent infection. Progress in the identification of different classes of compounds that block integrase activity has been summarized recently in several excellent reviews. Here, we present a brief overview of integrase inhibition, highlighting some of the unusual properties of this protein and important considerations in searching for potential new inhibitors and their evaluation.

引用

页码：717 / 731

页数：15

共 117 条

[11] Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends [J].

Chen, AP ;

Weber, IT ;

Harrison, RW ;

Leis, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (07) :4173-4182

[12] Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding [J].

Chen, JCH ;

Krucinski, J ;

Miercke, LJW ;

Finer-Moore, JS ;

Tang, AH ;

Leavitt, AD ;

Stroud, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (15) :8233-8238

[13] X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293) - An initial glance of the viral DNA binding platform [J].

Chen, ZG ;

Yan, YW ;

Munshi, S ;

Li, Y ;

Zugay-Murphy, J ;

Xu, B ;

Witmer, M ;

Felock, P ;

Wolfe, A ;

Sardana, V ;

Emini, EA ;

Hazuda, D ;

Kuo, LC .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 296 (02) :521-533

[14] Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75 [J].

Cherepanov, P ;

Ambrosio, ALB ;

Rahman, S ;

Ellenberger, T ;

Engelman, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (48) :17308-17313

[15] Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1 [J].

Cherepanov, P ;

Este, JA ;

Rando, RF ;

Ojwang, JO ;

Reekmans, G ;

Steinfeld, R ;

David, G ;

De Clercq, E ;

Debyser, Z .

MOLECULAR PHARMACOLOGY, 1997, 52 (05) :771-780

[16]

COFFIN JM, 1997, COLD SPRING HARBOR L, P161

[17] Characterization of the self association of avian sarcoma virus integrase by analytical ultracentrifugation [J].

Coleman, J ;

Eaton, S ;

Merkel, G ;

Skalka, AM ;

Laue, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :32842-32846

[18] A RAPID INVITRO ASSAY FOR HIV DNA INTEGRATION [J].

CRAIGIE, R ;

MIZUUCHI, K ;

BUSHMAN, FD ;

ENGELMAN, A .

NUCLEIC ACIDS RESEARCH, 1991, 19 (10) :2729-2734

[19] Caffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cells [J].

Daniel, R ;

Marusich, E ;

Argyris, E ;

Zhao, RY ;

Skalka, AM ;

Pomerantz, RJ .

JOURNAL OF VIROLOGY, 2005, 79 (04) :2058-2065

[20] Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway [J].

Daniel, R ;

Greger, JG ;

Katz, RA ;

Taganov, KD ;

Wu, XY ;

Kappes, JC ;

Skalka, AM .

JOURNAL OF VIROLOGY, 2004, 78 (16) :8573-8581

← 1 2 3 4 5 6 7 8 9 10 →