Embryo and fetotoxicity of hexavalent chromium: a long-term study

被引:62
作者
Kanojia, RK [1 ]
Junaid, M [1 ]
Murthy, RC [1 ]
机构
[1] Ind Toxicol Res Ctr, Met Anal Lab, Lucknow 226001, Uttar Pradesh, India
关键词
chromium (VI); drinking water; embryo and fetotoxicity; pregestational period; rats; three months;
D O I
10.1016/S0378-4274(98)00034-4
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Ingestion of chromium(VI) (250, 500 or 750 ppm as potassium dichromate, K2Cr2O7) through drinking water by female rats for 3 months prior to gestation was toxic to embryo and fetus. There was a significant reduction in number of implantations and number of fetuses and an increase in number of resorptions and pre-implantation and post-implantation losses. No significant visceral abnormality was found. The increase in the number of subdermal hemorrhagic patches on the thorax and abdomen was significant. Skeletal abnormality in the form of reduced ossification in parietal, interparietal and caudal bones was observed in fetuses. Chromium levels in the blood of mothers, placenta and fetuses showed a significant increase. Duration of the estrous cycle was also increased significantly. The study revealed that long-term chromium exposure in rats did not cause embryo and fetotoxicity in a duration-dependent manner compared to short-term treatment as observed earlier. A possible explanation could be that, in the 90-day study, the female rats did not mate for three estrous cycles, thus giving time for clearance of a sizable amount of chromium from their bodies. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:165 / 172
页数:8
相关论文
共 31 条
[21]  
*NIOSH, 1987, MAN AN METH
[22]  
Nriagu J.O., 1988, Chromium in the natural and human environments
[23]  
NRIAGU JO, 1988, CHROMIUM NATURAL HUM, P91
[24]  
Pribluda L.A., 1963, DOKL AKAD NAUK B SSR, V7, P206
[25]  
SHMITOVA L A, 1980, Gigiena Truda i Professional'nye Zabolevaniya, P33
[26]  
SHMITOVA LA, 1978, COURSE PREGNANCY WOM, P108
[27]  
STERN RM, 1981, ENV HLTH PERSPECT, V41, P335
[28]   EMBRYOTOXICITY AND FETOTOXICITY OF ORALLY-ADMINISTERED HEXAVALENT CHROMIUM IN MICE [J].
TRIVEDI, B ;
SAXENA, DK ;
MURTHY, RC ;
CHANDRA, SV .
REPRODUCTIVE TOXICOLOGY, 1989, 3 (04) :275-278
[29]   Chromium(VI) treatment of normal human lung cells results in guanine-specific DNA polymerase arrest, DNA-DNA cross-links and S-phase blockade of cell cycle [J].
Xu, J ;
Bubley, GJ ;
Detrick, B ;
Blankenship, LJ ;
Patierno, SR .
CARCINOGENESIS, 1996, 17 (07) :1511-1517
[30]  
YAMAGUCHI S, 1983, Industrial Health, V21, P25