Acquired gefitinib-resistant mutation of EGFR in a chemonaive lung adenocarcinoma harboring gefitinib-sensitive mutation L858R

被引:22
作者
Gow, CH [1 ]
Shih, JY [1 ]
Chang, YL [1 ]
Yu, CJ [1 ]
机构
[1] Natl Taiwan Univ Hosp, Taipei, Taiwan
来源
PLOS MEDICINE | 2005年 / 2卷 / 09期
关键词
D O I
10.1371/journal.pmed.0020269
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:924 / 925
页数:2
相关论文
共 6 条
[1]   EGFR mutation and resistance of non-small-cell lung cancer to gefitinib [J].
Kobayashi, S ;
Boggon, TJ ;
Dayaram, T ;
Janne, PA ;
Kocher, O ;
Meyerson, M ;
Johnson, BE ;
Eck, MJ ;
Tenen, DG ;
Halmos, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) :786-792
[2]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[3]   EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].
Paez, JG ;
Jänne, PA ;
Lee, JC ;
Tracy, S ;
Greulich, H ;
Gabriel, S ;
Herman, P ;
Kaye, FJ ;
Lindeman, N ;
Boggon, TJ ;
Naoki, K ;
Sasaki, H ;
Fujii, Y ;
Eck, MJ ;
Sellers, WR ;
Johnson, BE ;
Meyerson, M .
SCIENCE, 2004, 304 (5676) :1497-1500
[4]   Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain [J].
Pao, W ;
Miller, VA ;
Politi, KA ;
Riely, GJ ;
Somwar, R ;
Zakowski, MF ;
Kris, MG ;
Varmus, H .
PLOS MEDICINE, 2005, 2 (03) :225-235
[5]   EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib [J].
Pao, W ;
Miller, V ;
Zakowski, M ;
Doherty, J ;
Politi, K ;
Sarkaria, I ;
Singh, B ;
Heelan, R ;
Rusch, V ;
Fulton, L ;
Mardis, E ;
Kupfer, D ;
Wilson, R ;
Kris, M ;
Varmus, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (36) :13306-13311
[6]   Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways [J].
Sordella, R ;
Bell, DW ;
Haber, DA ;
Settleman, J .
SCIENCE, 2004, 305 (5687) :1163-1167