Immune cell signaling aberrations in human lupus

被引：21

作者：

Liossis, SNC ^{[1
]}

Sfikakis, PP

Tsokos, GC

机构：

[1] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Clin Physiol, Washington, DC 20307 USA

[2] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA

[3] Univ Athens, Sch Med, Dept Propaedeut Med 1, GR-11527 Athens, Greece

来源：

IMMUNOLOGIC RESEARCH | 1998年 / 18卷 / 01期

关键词：

systemic lupus erythematosus; human autoimmunity; lymphocytes; signal transduction; antigen receptor; costimulation;

D O I：

10.1007/BF02786511

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A large array of heterogeneous aberrations of the immune system have been described in systemic lupus erythematosus (SLE). Since the function and the fate of the immune system cells are governed principally by the biochemical events that follow ligation of specialized cell-surface receptors, we will review in this article recent developments in our understanding of abnormalities in the biochemistry of signals generated either by the antigen-receptor complex or by systems of costimulatory cell-surface molecules, like the CD28/CTLA4:CD80/CD86 and the CD40:CD40L pairs found on the surface membrane of lupus immune cells.

引用

收藏

页码：27 / 39

页数：13

相关论文

共 70 条

[11] The complexity of signaling pathways activated by the BCR [J].

DeFranco, AL .

CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (03) :296-308

[12] In situ expression of B7 and CD28 receptor families in skin lesions of patients with lupus erythematosus [J].

Denfeld, RW ;

Kind, P ;

Sontheimer, RD ;

Schopf, E ;

Simon, JC .

ARTHRITIS AND RHEUMATISM, 1997, 40 (05) :814-821

[13] Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production [J].

DesaiMehta, A ;

Lu, LJ ;

RamseyGoldman, R ;

Datta, SK .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (09) :2063-2073

[14] GENETIC-ANALYSIS OF THE NZB CONTRIBUTION TO LUPUS-LIKE AUTOIMMUNE-DISEASE IN (NZB X NZW)F-1 MICE [J].

DRAKE, CG ;

BABCOCK, SK ;

PALMER, E ;

KOTZIN, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :4062-4066

[15] PREVENTION OF COLLAGEN-INDUCED ARTHRITIS WITH AN ANTIBODY TO GP39, THE LIGAND FOR CD40 [J].

DURIE, FH ;

FAVA, RA ;

FOY, TM ;

ARUFFO, A ;

LEDBETTER, JA ;

NOELLE, RJ .

SCIENCE, 1993, 261 (5126) :1328-1330

[16] TREATMENT OF MURINE LUPUS WITH CTLA4IG [J].

FINCK, BK ;

LINSLEY, PS ;

WOFSY, D .

SCIENCE, 1994, 265 (5176) :1225-1227

[17] Analysis of CD80 and CD86 expression on peripheral blood B lymphocytes reveals increased expression of CD86 in lupus patients [J].

Folzenlogen, D ;

Hofer, MF ;

Leung, DYM ;

Freed, JH ;

Newell, MK .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1997, 83 (03) :199-204

[18] DEFECTIVE CD2 PATHWAY T-CELL ACTIVATION IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

FOX, DA ;

MILLARD, JA ;

TREISMAN, J ;

ZELDES, W ;

BERGMAN, A ;

DEPPER, J ;

DUNNE, R ;

MCCUNE, WJ .

ARTHRITIS AND RHEUMATISM, 1991, 34 (05) :561-571

[19] CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis [J].

Gerritse, K ;

Laman, JD ;

Noelle, RJ ;

Aruffo, A ;

Ledbetter, JA ;

Boersma, WJA ;

Claassen, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2499-2504

[20]

GRAMMER AC, 1995, J IMMUNOL, V154, P4996

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