Epigenetic control of Hox genes during neurogenesis, development, and disease

被引：72

作者：

Barber, Benjamin A. ^{[2
]}

Rastegar, Mojgan ^{[1
,2
,3
]}

机构：

[1] Univ Manitoba, Regenerat Med Program, Fac Med, Winnipeg, MB R3E 0J9, Canada

[2] Univ Manitoba, Dept Biochem & Med Genet, Winnipeg, MB R3E 0J9, Canada

[3] Univ Manitoba, Dept Immunol, Winnipeg, MB R3E 0J9, Canada

来源：

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2010年 / 192卷 / 05期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

Hox genes; Epigenetics; Neurogenesis; Chromatin structure; EMBRYONIC STEM-CELLS; ACID RESPONSE ELEMENT; DROSOPHILA HOMEOTIC GENES; PRIMORDIAL GERM-CELLS; FOOT-GENITAL SYNDROME; NEURAL STEM; HOMEOBOX GENES; NUCLEAR REORGANIZATION; DNA METHYLATION; TRANSCRIPTIONAL NETWORKS;

D O I：

10.1016/j.aanat.2010.07.009

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The process of mammalian development is established through multiple complex molecular pathways acting in harmony at the genomic proteomic and epigenomic levels The outcome is profoundly influenced by the role of epigenetics through transcriptional regulation of key developmental genes Epigenetics refer to changes in gene expression that are inherited through mechanisms other than the underlying DNA sequence which control cellular morphology and identity It is currently well accepted that epigenetics play central roles in regulating mammalian development and cellular differentiation by dictating cell fate decisions via regulation of specific genes Among these genes are the Hox family members, which are master regulators of embryonic development and stem cell differentiation and their mis-regulation leads to human disease and cancer The Hox gene discovery led to the establishment of a fundamental role for basic genetics in development Hox genes encode for highly conserved transcription factors from flies to humans that organize the anterior-posterior body axis during embryogenesis Hox gene expression during development is tightly regulated in a spatiotemporal manner partly by chromatin structure and epigenetic modifications Here we review the impact of different epigenetic mechanisms in development and stem cell differentiation with a clear focus on the regulation of Hox genes (C) 2010 Elsevier GmbH All rights reserved

引用

页码：261 / 274

页数：14

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