Ca2+ signaling in dendritic spines

被引:193
作者
Sabatini, BL [1 ]
Maravall, M [1 ]
Svoboda, K [1 ]
机构
[1] Howard Hughes Med Inst, Cold Spring Harbor Lab, Moscow 117437, Russia
关键词
D O I
10.1016/S0959-4388(00)00218-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dendritic spines are cellular microcompartments that are isolated from their parent dendrites and neighboring spines. Recently, imaging studies of spine Ca2+ dynamics have revealed that Ca2+ can enter spines through voltage-sensitive and ligand-activated channels, as well as through Ca2+ release from intracellular stores. Relationships between spine Ca2+ signals and induction of various forms of synaptic plasticity are beginning to be elucidated. Measurements of spine Ca2+ concentration are also being used to probe the properties of single synapses and even individual calcium channels in their native environment.
引用
收藏
页码:349 / 356
页数:8
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