Updates on p53: modulation of p53 degradation as a therapeutic approach

被引：63

作者：

Dey, A. ^{[1
]}

Verma, C. S. ^{[2
]}

Lane, D. P. ^{[1
]}

机构：

[1] Inst Mol & Cell Biol, Dept Cell Cycle Control, Singapore 138673, Singapore

[2] Bioinformat Inst, Singapore 138668, Singapore

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 98卷 / 01期

关键词：

p53; Mdm2 ( hdm2); Mdm4 ( MdmX; Hdm4; HdmX); small molecule inhibitors;

D O I：

10.1038/sj.bjc.6604098

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53 proteins. The pathway is critically controlled by protein degradation. Here, we discuss the latest developments in the search for small molecules that can modulate p53 pathway protein stability and restore p53 activity for cancer therapy.

引用

页码：4 / 8

页数：5

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