Tophus Measurement as an Outcome Measure for Clinical Trials of Chronic Gout: Progress and Research Priorities

被引：18

作者：

Dalbeth, Nicola ^{[1
]}

McQueen, Fiona M. ^{[1
]}

Singh, Jasvinder A. ^{[2
,3
]}

MacDonald, Patricia A. ^{[4
]}

Edwards, N. Lawrence ^{[5
]}

Schumacher, H. Ralph, Jr. ^{[6
,7
]}

Simon, Lee S. ^{[8
]}

Stamp, Lisa K. ^{[9
]}

Neogi, Tuhina ^{[10
]}

Gaffo, Angelo L. ^{[2
,3
]}

Khanna, Puja P. ^{[11
]}

Becker, Michael A. ^{[12
]}

Taylor, William J. ^{[13
]}

机构：

[1] Univ Auckland, Fac Med & Hlth Sci, Auckland 1, New Zealand

[2] Birmingham Vet Affairs VA Med Ctr, Birmingham, AL USA

[3] Univ Alabama, Birmingham, AL USA

[4] Takeda Global Res & Dev, Clin Sci, Deerfield, IL USA

[5] Univ Florida, Dept Med, Gainesville, FL USA

[6] Univ Penn, Philadelphia, PA 19104 USA

[7] VA Med Ctr, Philadelphia, PA USA

[8] SDG LLC, Med, Cambridge, MA USA

[9] Univ Otago, Dept Med, Christchurch, New Zealand

[10] Boston Univ, Sch Med, Boston, MA 02118 USA

[11] Univ Calif Los Angeles, David Geffen Sch Med, Div Rheumatol, Los Angeles, CA 90095 USA

[12] Univ Chicago, Rheumatol Sect, Chicago, IL 60637 USA

[13] Univ Otago, Dept Med, Wellington, New Zealand

来源：

JOURNAL OF RHEUMATOLOGY | 2011年 / 38卷 / 07期

关键词：

GOUT; TOPHUS; OUTCOME MEASURE; QUANTITATIVE-ANALYSIS; PHYSICAL MEASUREMENT; COMPUTED-TOMOGRAPHY; ALLOPURINOL; FEBUXOSTAT; URATE; HYPERURICEMIA; DOMAINS;

D O I：

10.3899/jrheum.110272

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Despite the recognition that tophus regression is an important outcome measure in clinical trials of chronic gout, there is no agreed upon method of tophus measurement. A number of methods have been used in clinical trials of chronic gout, from simple physical measurement techniques to more complex advanced imaging methods. This article summarizes methods of tophus measurement and discusses their properties. Physical measurement using Vernier calipers meets most aspects of the Outcome Measures in Rheumatology (OMERACT) filter. Rigorous testing of the complex methods, particularly with respect to reliability and sensitivity to change, is needed to determine the appropriate use of these methods. Further information is also required regarding which method of physical measurement is best for use in future clinical trials. The need to develop and test a patient-reported outcome measure of tophus burden is also highlighted. (J Rheumatol 2011;38:1458-61; doi:10.3899/jrheum.110272)

引用

页码：1458 / 1461

页数：4

共 17 条

[1]

Febuxostat compared with allopurinol in patients with hyperuricemia and gout [J].