Glucose plus insulin infusion improves cerebral outcome after asphyxial cardiac arrest

被引：38

作者：

Katz, LM

Wang, YF

Ebmeyer, U

Radovsky, A

Safar, P

机构：

[1] Univ N Carolina, UNC Hosp, Dept Emergency Med, Chapel Hill, NC 27599 USA

[2] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA 15260 USA

[4] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA

[5] Univ Pittsburgh, Sch Med, Natl Inst Environm Hlth Serv, Pittsburgh, PA 15260 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 15期

关键词：

asphyxia; cardiopulmonary resuscitation; cerebral ischemia; hyperglycemia; rats;

D O I：

10.1097/00001756-199810260-00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

HYPERGLYCEMIA before ischemia worsens cerebral outcome. The aim of this study was to determine the cerebral effects of giving glucose with or without insulin after asphyxial cardiac arrest. Rats underwent 8 min of asphyxial cardiac arrest. After arrest, Group 1 received NaCl; Group 2, insulin; Group 3, glucose; and Group 4, glucose plus insulin, all intravenously. Neurological deficit (ND) scores were 14 +/- 10%, 22 +/- 12%, 12 +/- 10% and 2 +/- 2% in Groups 1-4, respectively, 72 h after reperfusion. Overall histological damage (HD) scores were 4, 2, 3 and I, respectively. Group 4 fared significantly better than group 1 on both scores. Glucose after asphyxial cardiac arrest in rats produces no increased brain damage while glucose plus insulin improves cerebral outcome. (C) 1998 Lippincott Williams & Wilkins.

引用

页码：3363 / 3367

页数：5

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[11] OUTCOME MODEL OF ASPHYXIAL CARDIAC-ARREST IN RATS [J].