Palladium-catalyzed alkylation-hydride reduction sequence: Synthesis of meta-substituted arenes

被引：79

作者：

Wilhelm, T ^{[1
]}

Lautens, M ^{[1
]}

机构：

[1] Univ Toronto, John & Edna Davenport Chem Res Labs, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 18期

关键词：

D O I：

10.1021/ol051628n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new three-component, palladium-catalyzed domino reaction which gives access to meta-Substituted arenes using aryl iodides and primary alkyl halides is reported. Various functional groups are tolerated on both the aryl iodide and alkyl halide. In addition, isotopic labeling studies provide insight into the mechanism of this Catellani-type reaction.

引用

页码：4053 / 4056

页数：4