Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells

被引：48

作者：

Kolodziej, H

Burmeister, A

Trun, W

Radtke, OA

Kiderlen, AF

Ito, H

Hatano, T

Yoshida, T

Foo, LY

机构：

[1] Free Univ Berlin, Inst Pharm, D-14195 Berlin, Germany

[2] Robert Koch Inst, Dept Infect Dis, D-13353 Berlin, Germany

[3] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

[4] Ind Res Ltd, Lower Hutt, New Zealand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 23期

关键词：

Leishmania major; macrophages; proanthocyanidins; hydrolysable tannins; polyphenols; inducible nitric oxide synthase; cytokines; gene expression analysis;

D O I：

10.1016/j.bmc.2005.07.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some polyphenol-containing extracts (Pelargonium sidoides, Phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-O-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (NOS, IL-1, IL-10, IL-12, IL-18, TNF-alpha, IFN-alpha/gamma) by RT-PCR. All extracts and compounds were capable of enhancing the NOS and cytokine mRNA levels in parasitised cells when compared with those in non-infected conditions. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6470 / 6476

页数：7

共 51 条

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