Natural Killer Cell Responses to Viral Infection

被引：132

作者：

Brandstadter, Joshua D. ^{[2
]}

Yang, Yiping ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Mol Canc Biol Program, Durham, NC 27710 USA

来源：

JOURNAL OF INNATE IMMUNITY | 2011年 / 3卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Natural killer cells; Viral infection; Innate immunity; HUMAN NK CELLS; IFN-GAMMA PRODUCTION; DOUBLE-STRANDED-RNA; INHIBITORY RECEPTORS; CYTOMEGALOVIRUS-INFECTION; DENDRITIC CELLS; ACTIVATION RECEPTOR; ANTIVIRAL DEFENSE; NKG2D; CYTOTOXICITY;

D O I：

10.1159/000324176

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells, as part of the innate immune system, play a key role in host defense against viral infections. Recent advances have indicated that NK cell activation and function are regulated by the interplay between inhibitory and activating signals. Thus, a better understanding of mechanisms responsible for NK cell activation and function in the control of viral infections will help develop NK cell-based therapies. In this review, we will first discuss how NK cells are activated in response to viral infections. We will then focus on the recruitment of activated NK cells to the site of infection as well as on NK cell effector mechanisms against virally infected cells. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：274 / 279

页数：6

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