DNA copy number changes in familial malignant mesothelioma

被引：22

作者：

Ascoli, V

Aalto, Y

Carnovale-Scalzo, C

Nardi, F

Falzetti, D

Mecucci, C

Knuutila, S

机构：

[1] Univ La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy

[2] Univ Perugia, Dept Hematol, I-06100 Perugia, Italy

[3] Univ Helsinki, Haartman Inst, Dept Med Genet, Helsinki, Finland

[4] Univ Helsinki, Cent Hosp, Helsinki, Finland

来源：

CANCER GENETICS AND CYTOGENETICS | 2001年 / 127卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(00)00420-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant mesothelioma (MM) is predominantly a sporadic malignancy linked to exposure to asbestos. Clustering of MM in families suggests genetic susceptibility as a contributing factor. We performed comparative genomic hybridization (CGH) analysis on tumor samples from members of a family with MM of the pleura and a history of parental cancer. Our specific aim was to find a recurrent copy number loss indicating the chromosomal area to which a gene underlying the development of MM could be assigned according to the Knudson two-hit hypothesis. We found losses at 1p, 6q. 9p. 13q, and 14q. The copy number changes were very similar to those reported in sporadic cases. Our findings and results from sporadic cases highlight the importance of cloning the genes in the loss sites at 1p, 6q, 14q, and 22q. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：80 / 82

页数：3