The immunopathology of Guillain-Barre syndrome

被引：6

作者：

Saida, K

机构：

来源：

CURRENT OPINION IN NEUROLOGY | 1996年 / 9卷 / 05期

关键词：

D O I：

10.1097/00019052-199610000-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Identification of new antigens in different patterns of Guillain-Barre syndrome has led to new pathophysiological concepts of Guillain-Barre syndrome and the related Miller-Fisher syndrome. Patients with Guillain-Barre syndrome occurring after Campylobacter jejuni infection have been found to develop more frequently axonal and motor forms of the syndrome. Anti-GM1 antibodies decreased Na+ current in the presence of complement. In acute axonal Guillain-Barre syndrome, macrophages were found in the periaxonal space without damaging myelin sheath. Important epitopes may be localized on the axolemma, but further studies are needed to confirm these observations.

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页码：329 / 333

页数：5

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