Resveratrol and its impact on aging and thyroid function

被引：27

作者：

Duntas, L. H. ^{[1
]}

机构：

[1] Univ Athens, Endocrine Unit, Evgenid Hosp, Athens 11528, Greece

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2011年 / 34卷 / 10期

关键词：

The French-paradox; resveratrol; sirtuins; thyroid; thyroid cancer; RED WINE; TRANS-RESVERATROL; INSULIN SENSITIVITY; CHALCONE SYNTHASES; FRENCH PARADOX; SIRT1; BIOAVAILABILITY; CANCER; CONSUMPTION; INHIBITION;

D O I：

10.3275/7926

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Resveratrol, the naturally occurring polyphenolic compound characterized by anti-oxidative, anti-inflammatory and apoptotic properties, appears to contribute substantially to cardioprotection and cancer-prevention. In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and aging, by modulating the mammalian silent information regulator 1 (SIRT1) of the sirtuin family. Resveratrol may arrest, among various tumors, cell growth in both papillary and follicular thyroid cancer by activation of the mitogen-activated protein kinase (MAPK) signal transduction pathway as well as increase of p53 and its phosphorylation. Finally, resveratrol also influences thyroid function by enhancing iodide trapping and, by increasing TSH secretion via activation of sirtuins and the phosphatidylinosito1-4-phosphate 5 kinase gamma (PIP5K gamma) pathway, positively affects metabolism. (J. Endocrinol. Invest. 34: 788-792, 2011) (C)2011, Editrice Kurtis

引用

页码：788 / 792

页数：5

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