Sirtuin activators: Designing molecules to extend life span

被引：62

作者：

Camins, Antoni ^{[1
]}

Sureda, Francesc X. ^{[2
]}

Junyent, Felix ^{[1
,3
]}

Verdaguer, Ester ^{[1
]}

Folch, Jaume ^{[3
]}

Pelegri, Carme ^{[5
]}

Vilaplana, Jordi ^{[5
]}

Beas-Zarate, Carlos ^{[4
]}

Pallas, Merce ^{[1
]}

机构：

[1] Univ Barcelona, Fac Farm,Nucli Univ Pedralbes, Inst Biomed IBUB,Unitat Farmacol & Farmacognosia, Ctr Invest Biomed Red Enfermedades Neurodegenerat, E-08028 Barcelona, Spain

[2] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Farmacol, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Tarragona 43201, Spain

[3] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Bioquim, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Tarragona 43201, Spain

[4] Univ Guadalajara, Div Neurociencias, Ctr Invest Biomed Occidente, Dept Biol Celular & Mol,CUCBA,IMSS, Guadalajara 44340, Jalisco, Mexico

[5] Univ Barcelona, Fac Farm, Dept Fisiol, Ctr Invest Biomed Red Enfermedades Neurodegenerat, E-08028 Barcelona, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2010年 / 1799卷 / 10-12期

关键词：

Sirtuins; Resveratrol; Neurodegenerative diseases; Diabetes; Sirtuin activators; PROTECTS DOPAMINERGIC-NEURONS; DECREASES ADIPOCYTE FORMATION; VS. INACTIVE CHROMATIN; SOMATIC H1 SUBTYPES; OXIDATIVE STRESS; RED WINE; RESVERATROL PROTECTS; CALORIE RESTRICTION; ALZHEIMERS-DISEASE; OSTEOBLAST DIFFERENTIATION;

D O I：

10.1016/j.bbagrm.2010.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Resveratrol (RESV) exerts important pharmacological effects on human health: in addition to its beneficial effects on type 2 diabetes and cardiovascular diseases, it also modulates neuronal energy homeostasis and shows antiaging properties. Although it clearly has free radical scavenger properties, the mechanisms involved in these beneficial effects are not fully understood. In this regard, one area of major interest concerns the effects of RESV on the activity of sirtuin 1 (SIRT1), an NAD(+)-dependent histone deacetylase that has been implicated in aging. Indeed, the role of SIRT1 is currently the subject of intense research due to the antiaging properties of RESV, which increases life span in various organisms ranging from yeast to rodents. In addition, when RESV is administered in experimental animal models of neurological disorders, it has similar beneficial effects to caloric restriction. SIRT1 activation could thus constitute a potential strategic target in neurodegenerative diseases and in disorders involving disturbances in glucose homeostasis, as well as in dyslipidaemias or cardiovascular diseases. Therefore, small SIRT1 activators such as SRT501, SRT2104, and SRT2379, which are currently undergoing clinical trials, could be potential drugs for the treatment of type 2 diabetes, obesity, and metabolic syndrome, among other disorders. This review summarises current knowledge about the biological functions of SIRT1 in aging and aging-associated diseases and discusses its potential as a pharmacological target. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：740 / 749

页数：10

共 103 条

[1]

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide [J].