A soluble receptor decoy protects rats against anthrax lethal toxin challenge

被引：76

作者：

Scobie, HM

Thomas, D

Marlett, JM

Destito, G

Wigelsworth, DJ

Collier, RJ

Young, JAT

Manchester, M

机构：

[1] Scripps Res Inst, Dept Cell Biol, Ctr Integrat Mol Biosci, La Jolla, CA 92037 USA

[2] Salk Inst Biol Studies, Infect Dis Lab, La Jolla, CA 92037 USA

[3] Univ Wisconsin, Cell & Mol Biol Grad Program, Madison, WI USA

[4] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

[5] Univ Magna Graecia Catanzaro, Dipartimento Med Sperimentale & Clin, Catanzaro, Italy

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 06期

关键词：

D O I：

10.1086/432731

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Successful postexposure treatment for inhalation anthrax is thought to include neutralization of anthrax toxin. The soluble anthrax toxin receptor/tumor endothelial marker 8 and capillary morphogenesis protein 2 (sATR/TEM8 and sCMG2, respectively) receptor decoys bind to anthrax toxin protective antigen (PA) and compete with cellular receptors for binding. Here, we show that, in a tissue-culture model of intoxication, sCMG2 is a 11.4-fold more potent antitoxin than sATR/TEM8 and that this increased activity corresponds to an similar to 1000- fold higher PA-binding affinity. Stoichiometric concentrations of sCMG2 protect rats against lethal toxin challenge, making sCMG2 one of the most effective anthrax antitoxins described to date.

引用

收藏

页码：1047 / 1051

页数：5

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