Antitoxins: Novel strategies to target agents of bioterrorism

被引：93

作者：

Rainey, GJA ^{[1
]}

Young, JAT ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Infect Dis Lab, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 09期

关键词：

D O I：

10.1038/nrmicro977

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Never before has there been such a strong possibility that biological agents might be used indiscriminately on civilian populations. This review focuses on the use of antitoxins antibodies, receptor decoys, dominant-negative inhibitors of translocation, small-molecule inhibitors and substrate analogues-to counteract those biological weapons for which toxins are an important mechanism of disease pathogenesis.

引用

页码：721 / 726

页数：6

共 46 条

[1] Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process [J].

Abrami, L ;

Liu, SH ;

Cosson, P ;

Leppla, SH ;

van der Goot, FG .

JOURNAL OF CELL BIOLOGY, 2003, 160 (03) :321-328

[2] Efficacy of a novel metalloprotease inhibitor on botulinum neurotoxin B activity [J].

Adler, M ;

Nicholson, JD ;

Hackley, BE .

FEBS LETTERS, 1998, 429 (03) :234-238

[3] Development of potent inhibitors of botulinum neurotoxin type B [J].

Anne, C ;

Turcaud, S ;

Quancard, J ;

Teffo, F ;

Meudal, H ;

Fournié-Zaluski, MC ;

Roques, BP .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (22) :4648-4656

[4]

Bradberry Sally M., 2003, Toxicological Reviews, V22, P65, DOI 10.2165/00139709-200322010-00007

[5] Identification of the cellular receptor for anthrax toxin [J].

Bradley, KA ;

Mogridge, J ;

Mourez, M ;

Collier, RJ ;

Young, JAT .

NATURE, 2001, 414 (6860) :225-229

[6] Binding of anthrax toxin to its receptor is similar to α integrin-ligand interactions [J].

Bradley, KA ;

Mogridge, J ;

Rainey, GJA ;

Batty, S ;

Young, JAT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (49) :49342-49347

[7] Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity [J].

Burnett, JC ;

Schmidt, JJ ;

Stafford, RG ;

Panchal, RG ;

Nguyen, TL ;

Hermone, AR ;

Vennerstrom, JL ;

McGrath, CF ;

Lane, DJ ;

Sausville, EA ;

Zaharevitz, DW ;

Gussio, R ;

Bavari, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 310 (01) :84-93

[8] Anthrax toxin [J].

Collier, RJ ;

Young, JAT .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2003, 19 :45-70

[9] Potent inhibitors of anthrax lethal factor from green tea [J].

Dell'Aica, I ;

Donà, M ;

Tonello, F ;

Piris, A ;

Mock, M ;

Montecucco, C ;

Garbisa, S .

EMBO REPORTS, 2004, 5 (04) :418-422

[10] Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells [J].

Dong, M ;

Richards, DA ;

Goodnough, MC ;

Tepp, WH ;

Johnson, EA ;

Chapman, ER .

JOURNAL OF CELL BIOLOGY, 2003, 162 (07) :1293-1303

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