Mechanisms regulating epidermal stem cells

被引：44

作者：

Beck, Benjamin ^{[1
]}

Blanpain, Cedric ^{[1
,2
]}

机构：

[1] Univ Libre Bruxelles, Interdisciplinary Res Inst IRIBHM, B-1070 Brussels, Belgium

[2] Univ Libre Bruxelles, WELBIO, B-1070 Brussels, Belgium

来源：

EMBO JOURNAL | 2012年 / 31卷 / 09期

关键词：

epigenetics; keratinocytes; lineage tracing; micro-RNA; stem cells; LABEL-RETAINING CELLS; HAIR FOLLICLE BULGE; C-MYC; LINEAGE DIFFERENTIATION; GENE-EXPRESSION; SELF-RENEWAL; P53; HOMOLOG; P63; PROLIFERATION; POPULATION;

D O I：

10.1038/emboj.2012.67

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The skin epidermis contains different appendages such as the hair follicle and the sebaceous glands. Recent studies demonstrated that several types of stem cells (SCs) exist in different niches within the epidermis and maintain discrete epidermal compartments, but the exact contribution of each SC populations under physiological conditions is still unclear. In addition, the precise mechanisms controlling the balance between proliferation and differentiation of epidermal SC still remain elusive. Recent studies provide new insights into these important questions by showing the contribution of hair follicle SC to the sebaceous lineage and the importance of chromatin modifications and micro-RNAs (miRs) in regulating epidermal SCs renewal and differentiation. In this review, we will discuss the importance of these papers to our understanding of the mechanisms that control epidermal SC functions. The EMBO Journal (2012) 31, 2067-2075. doi:10.1038/emboj.2012.67; Published online 20 March 2012

引用

页码：2067 / 2075

页数：9

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