Pharmacokinetics of ciprofloxacin in eels by high-performance liquid chromatography with fluorescence detection

The plasma kinetics of ciprofloxacin (CF) were investigated in the eels after administration by oral gavage and bath treatment. Plasma concentrations of CF were determined by high-performance liquid chromatography with fluorescence detection. The mean concentration time data after oral gavage of a single dose (10.0 mg/kg CF) and after bath treatment by exposure (10 mu g/ml CF) to medicated water for 48 h were both best fitted by a one-compartment model. After oral gavage in eels, the half-time of absorption (T-1/2Ka) was 0.10 h, the half-time of elimination (T-1/2Ke) was 51.87 h, and the maximum plasma concentration (C-max) was 0.4552 mu g/ ml at T-max 0.88 h. After bath treatment, the T-1/2Ka was 0.02 h, the T-1/2Ke was 15.46 h, and the C-max was 0.1175 mu g/mL at T-max 0.22 h. (c) 2005 Elsevier Inc. All rights reserved.