aThe faithful repair of DNA damage, especially chromosomal double-strand breaks (DSBs), is crucial for genomic integrity. We have previously shown that securin interacts with the Ku70/80 heterodimer of the DSB non-homologous DNA end-joining (NHEJ) repair machinery. Here we demonstrate that securin deficiency compromises cell survival and proliferation, but only after genotoxic stress. Securin(-/-) cells show a significant increase in gross chromosomal rearrangements and chromatid breaks after DNA damage, and also reveal an altered pattern of end resection in an NHEJ assay in comparison with securin(+/+) cells. These data suggest that securin has a key role in the maintenance of genomic stability after DNA damage, thereby providing a previously unknown mechanism for regulating tumour progression.
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Yokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, JapanYokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, Japan
Adachi, N
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So, SR
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Yokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, JapanYokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, Japan
So, SR
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Koyama, H
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Yokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, JapanYokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, Japan
机构:Univ Stockholm, Wallenberg Lab, Dept Genet & Cellular Toxicol, S-10691 Stockholm, Sweden
Arnaudeau, C
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Lundin, C
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机构:Univ Stockholm, Wallenberg Lab, Dept Genet & Cellular Toxicol, S-10691 Stockholm, Sweden
Lundin, C
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Helleday, T
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机构:
Univ Stockholm, Wallenberg Lab, Dept Genet & Cellular Toxicol, S-10691 Stockholm, SwedenUniv Stockholm, Wallenberg Lab, Dept Genet & Cellular Toxicol, S-10691 Stockholm, Sweden
机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
Ferguson, DO
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Sekiguchi, JM
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机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
Sekiguchi, JM
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机构:
Chang, S
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Frank, KM
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机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
Frank, KM
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Gao, YJ
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机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
Gao, YJ
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DePinho, RA
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机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
DePinho, RA
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Alt, FW
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h-index: 0
机构:
Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USAChildrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
机构:
Yokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, JapanYokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, Japan
Adachi, N
;
So, SR
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, JapanYokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, Japan
So, SR
;
Koyama, H
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h-index: 0
机构:
Yokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, JapanYokohama City Univ, Kihara Inst Biol Res, Grad Sch Integrated Sci, Totsuka Ku, Yokohama, Kanagawa 2440813, Japan
机构:Univ Stockholm, Wallenberg Lab, Dept Genet & Cellular Toxicol, S-10691 Stockholm, Sweden
Arnaudeau, C
;
Lundin, C
论文数: 0引用数: 0
h-index: 0
机构:Univ Stockholm, Wallenberg Lab, Dept Genet & Cellular Toxicol, S-10691 Stockholm, Sweden
Lundin, C
;
Helleday, T
论文数: 0引用数: 0
h-index: 0
机构:
Univ Stockholm, Wallenberg Lab, Dept Genet & Cellular Toxicol, S-10691 Stockholm, SwedenUniv Stockholm, Wallenberg Lab, Dept Genet & Cellular Toxicol, S-10691 Stockholm, Sweden
机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
Ferguson, DO
;
Sekiguchi, JM
论文数: 0引用数: 0
h-index: 0
机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
Sekiguchi, JM
;
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机构:
Chang, S
;
Frank, KM
论文数: 0引用数: 0
h-index: 0
机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
Frank, KM
;
Gao, YJ
论文数: 0引用数: 0
h-index: 0
机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
Gao, YJ
;
DePinho, RA
论文数: 0引用数: 0
h-index: 0
机构:Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA
DePinho, RA
;
Alt, FW
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USAChildrens Hosp, Howard Hughes Med Inst, Ctr Blood Res, Boston, MA 02115 USA