Control of RNA processing by a large non-coding RNA over-expressed in carcinomas

被引：75

作者：

Lin, Rui ^{[1
]}

Roychowdhury-Saha, Manami ^{[1
]}

Black, Chris ^{[2
]}

Watt, Andrew T. ^{[2
]}

Marcusson, Eric G. ^{[2
]}

Freier, Susan M. ^{[2
]}

Edgington, Thomas S. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] ISIS Pharmaceut, Carlsbad, CA 92008 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 04期

关键词：

Hepcarcin; Sigma RNA/MALAT-1; RNA processing; Alternative splicing; TISSUE FACTOR GENE; CANCER; CELLS; METASTASIS; SEQUENCE; ENDOGLIN; MALAT-1;

D O I：

10.1016/j.febslet.2011.01.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not fully established. Sigma RNA is a class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-regulated in carcinomas. Using antisense technology, we identified that RNA post-transcriptional modification is the most significant global function of Sigma RNA. Specifically, processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by hydrolysis of Sigma RNA/MALAT-1. These results support the hypothesis that Sigma RNA/MALAT-1 is a regulatory molecule exerting roles in RNA post-transcriptional modification. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：671 / 676

页数：6