The POU factor Oct-6 and Schwann cell differentiation

被引：231

作者：

Jaegle, M ^{[1
]}

Mandemakers, W ^{[1
]}

Broos, L ^{[1
]}

Zwart, R ^{[1
]}

Karis, A ^{[1
]}

Visser, P ^{[1
]}

Grosveld, F ^{[1
]}

Meijer, D ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM, DEPT CELL BIOL & GENET, NL-3000 DR ROTTERDAM, NETHERLANDS

来源：

SCIENCE | 1996年 / 273卷 / 5274期

关键词：

D O I：

10.1126/science.273.5274.507

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

引用

页码：507 / 510

页数：4

共 20 条

[1]

[Anonymous], INTRO MOL NEUROBIOLO

[2] TST-1, A MEMBER OF THE POU DOMAIN GENE FAMILY, BINDS THE PROMOTER OF THE GENE ENCODING THE CELL-SURFACE ADHESION MOLECULE PO [J].

HE, X ;

GERRERO, R ;

SIMMONS, DM ;

PARK, RE ;

LIN, CJR ;

SWANSON, LW ;

ROSENFELD, MG .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (03) :1739-1744

[3]

Jessen K R, 1992, Curr Opin Neurobiol, V2, P575, DOI 10.1016/0959-4388(92)90021-C

[4] THE SCHWANN-CELL PRECURSOR AND ITS FATE - A STUDY OF CELL-DEATH AND DIFFERENTIATION DURING GLIOGENESIS IN RAT EMBRYONIC NERVES [J].

JESSEN, KR ;

BRENNAN, A ;

MORGAN, L ;

MIRSKY, R ;

KENT, A ;

HASHIMOTO, Y ;

GAVRILOVIC, J .

NEURON, 1994, 12 (03) :509-527

[5] PAX3 - A PAIRED DOMAIN GENE AS A REGULATOR IN PNS MYELINATION [J].

KIOUSSI, C ;

GROSS, MK ;

GRUSS, P .

NEURON, 1995, 15 (03) :553-562

[6] PATTERNING OF NEURAL CREST DERIVATIVES IN THE AVIAN EMBRYO - IN-VIVO AND IN-VITRO STUDIES [J].

LEDOUARIN, NM ;

ZILLER, C ;

COULY, GF .

DEVELOPMENTAL BIOLOGY, 1993, 159 (01) :24-49

[7] THE OCTAMER BINDING-FACTOR OCT6 - CDNA CLONING AND EXPRESSION IN EARLY EMBRYONIC-CELLS [J].

MEIJER, D ;

GRAUS, A ;

KRAAY, R ;

LANGEVELD, A ;

MULDER, MP ;

GROSVELD, G .

NUCLEIC ACIDS RESEARCH, 1990, 18 (24) :7357-7365

[8] Schwann cell development, differentiation and myelination [J].

Mirsky, R ;

Jessen, KR .

CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (01) :89-96

[9] REPRESSION OF THE MYELIN-P(0) GENE BY THE POU TRANSCRIPTION FACTOR SCIP [J].

MONUKI, ES ;

KUHN, R ;

LEMKE, G .

MECHANISMS OF DEVELOPMENT, 1993, 42 (1-2) :15-32

[10] EXPRESSION AND ACTIVITY OF THE POU TRANSCRIPTION FACTOR SCIP [J].

MONUKI, ES ;

KUHN, R ;

WEINMASTER, G ;

TRAPP, BD ;

LEMKE, G .

SCIENCE, 1990, 249 (4974) :1300-1303

← 1 2 →