TST-1, A MEMBER OF THE POU DOMAIN GENE FAMILY, BINDS THE PROMOTER OF THE GENE ENCODING THE CELL-SURFACE ADHESION MOLECULE PO

Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein Po, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the Po promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.