Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

被引：157

作者：

Canli, T

Congdon, E

Gutknecht, L

Constable, RT

Lesch, KP

机构：

[1] Univ Wurzburg, Dept Psychiat & Psychotherapy, D-97080 Wurzburg, Germany

[2] SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11794 USA

[3] SUNY Stony Brook, Grad Program Genet, Stony Brook, NY 11794 USA

[4] Yale Univ, MRRC, New Haven, CT USA

来源：

JOURNAL OF NEURAL TRANSMISSION | 2005年 / 112卷 / 11期

关键词：

tryptophan hydroxylase-2 gene; amygdala; functional imaging;

D O I：

10.1007/s00702-005-0391-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

引用

页码：1479 / 1485

页数：7

共 22 条

[1]

[Anonymous], 1992, PROFILE MOOD STATES

[2] A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity [J].