Cognitive inflexibility after prefrontal serotonin depletion

被引：479

作者：

Clarke, HF

Dalley, JW

Crofts, HS

Robbins, TW

Roberts, AC

机构：

[1] Univ Cambridge, Dept Anat, Cambridge, England

[2] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

来源：

SCIENCE | 2004年 / 304卷 / 5672期

关键词：

D O I：

10.1126/science.1094987

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Serotonergic dysregulation within the prefrontal cortex (PFC) is implicated in many neuropsychiatric disorders, but the precise role of serotonin within the PFC is poorly understood. Using a serial discrimination reversal paradigm, we showed that upon reversal, selective serotonin depletion of the marmoset PFC produced perseverative responding to the previously rewarded stimulus without any significant effects on either retention of a discrimination learned preoperatively or acquisition of a novel discrimination postoperatively. These results highlight the importance of prefrontal serotonin in behavioral flexibility and are highly relevant to obsessive-compulsive disorder, schizophrenia, and the cognitive sequelae of drug abuse in which perseveration is prominent.

引用

页码：878 / 880

页数：3

共 28 条

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