An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems

被引：70

作者：

Ho, PP

Fontoura, P

Ruiz, PJ

Steinman, L

Garren, H

机构：

[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Beckman Ctr Mol Med, Stanford, CA 94305 USA

[2] Calif Pacific Med Ctr, Dept Med, San Francisco, CA 94115 USA

[3] Univ Lisbon, Hosp Egas Moniz, Dept Neurol, P-1699 Lisbon, Portugal

[4] Bayhill Therapeut Inc, Palo Alto, CA 94303 USA

来源：

JOURNAL OF IMMUNOLOGY | 2003年 / 171卷 / 09期

关键词：

D O I：

10.4049/jimmunol.171.9.4920

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial DNA and immunostimulatory CpG oligodeoxynucleotides (ODNs) activate the innate immune system to produce proinflammatory cytokines. Shown to be potent Th1-like adjuvants, stimulatory CpG motifs are currently used as effective therapeutic vaccines for various animal models of infectious diseases, tumors, allergies, and autoimmune diseases. In this study, we show that the application of an immunomodulatory GpG ODN, with a single base switch from CpG to GpG, can effectively inhibit the activation of Th1 T cells associated with autoimmune disease. Moreover, this immunomodulatory GpG ODN suppresses the severity of experimental autoimmune encephalomyelitis in mice, a prototypic Th1-mediated animal disease model for multiple sclerosis.

引用

收藏

页码：4920 / 4926

页数：7

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