Two novel cyclic peptides with antifungal activity from the cyanobacterium Tolypothrix byssoidea (EAWAG 195)

被引：52

作者：

Jaki, B ^{[1
]}

Zerbe, O ^{[1
]}

Heilmann, J ^{[1
]}

Sticher, O ^{[1
]}

机构：

[1] ETH Zurich, Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Appl Biosci, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 02期

关键词：

D O I：

10.1021/np000297e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel cyclic tridecapeptides, tolybyssidins A (1) and B (2), were isolated from the culture medium of mass cultured cyanobacterium Tolypothrix byssoidea (EAWAG 195) by means of bioguided isolation. The gross structures of these peptides were determined by 1D and 2D NMR experiments and tandem mass spectrometry. Both peptides contain the nonnatural amino acid dehydrohomoalanine (Dhha) as well as proteinogenic amino acids albeit with D- or L-configuration. The compounds exhibit moderate antifungal activity against the yeast Candida albicans.

引用

页码：154 / 158

页数：5

共 14 条

[11] BIOACTIVE NATURAL-PRODUCTS FROM BLUE-GREEN-ALGAE [J].