A systems biology perspective on plant-microbe interactions: Biochemical and structural targets of pathogen effectors

被引：45

作者：

Pritchard, Leighton ^{[2
]}

Birch, Paul ^{[1
,2
]}

机构：

[1] SCRI, Univ Dundee, Div Plant Sci, Dundee DD2 5DA, Scotland

[2] SCRI, Plant Pathol Programme, Dundee DD2 5DA, Scotland

来源：

PLANT SCIENCE | 2011年 / 180卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Pathogen; Effector; Network; Systems biology; Modelling; PSEUDOMONAS-SYRINGAE; SACCHAROMYCES-CEREVISIAE; DISEASE-RESISTANCE; NETWORK MOTIFS; CONNECTIVITY STRUCTURE; BACTERIAL VIRULENCE; FUNCTIONAL GENOMICS; REGULATORY NETWORKS; DEFENSE RESPONSES; ESCHERICHIA-COLI;

D O I：

10.1016/j.plantsci.2010.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plants have biochemical defences against stresses from predators, parasites and pathogens. In this review we discuss the interaction of plant defences with microbial pathogens such as bacteria, fungi and oomycetes, and viruses. We examine principles of complex dynamic networks that allow identification of network components that are differentially and predictably sensitive to perturbation, thus making them likely effector targets. We relate these principles to recent developments in our understanding of known effector targets in plant-pathogen systems, and propose a systems-level framework for the interpretation and modelling of host-microbe interactions mediated by effectors. We describe this framework briefly, and conclude by discussing useful experimental approaches for populating this framework. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：584 / 603

页数：20

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