BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk

被引:704
作者
Miyazono, K
Maeda, S
Imamura, T
机构
[1] Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Bunkyo Ku, Tokyo 1130033, Japan
[2] Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Koto Ku, Tokyo 1358550, Japan
关键词
BMP; TGF-beta; serine/threonine kinase receptor; Smad; signaling cross-talk;
D O I
10.1016/j.cytogfr.2005.01.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various proteins, including transcription factor Runx, and transmit specific signals in target cells. The recent development of DNA microarray techniques has allowed us to identify many BMP target genes. BMP signaling is modulated by various molecules, including inhibitory Smads (I-Smads). Moreover, recent findings have revealed that BMP pathways interact with other signaling pathways, and such signaling cross-talk plays pivotal roles in growth and differentiation of target cells. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:251 / 263
页数:13
相关论文
共 130 条
  • [91] CD44 modulates Smad1 activation in the BMP-7 signaling pathway
    Peterson, RS
    Andhare, RA
    Rousche, KT
    Knudson, W
    Wang, WH
    Grossfield, JB
    Thomas, RO
    Hollingsworth, RE
    Knudson, CB
    [J]. JOURNAL OF CELL BIOLOGY, 2004, 166 (07) : 1081 - 1091
  • [92] The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis
    Podos, SD
    Hanson, KK
    Wang, YC
    Ferguson, EL
    [J]. DEVELOPMENTAL CELL, 2001, 1 (04) : 567 - 578
  • [93] Smad3 allostery links TGF-β receptor kinase activation to transcriptional control
    Qin, BY
    Lam, SS
    Correia, JJ
    Lin, K
    [J]. GENES & DEVELOPMENT, 2002, 16 (15) : 1950 - 1963
  • [94] SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1
    Raju, GP
    Dimova, N
    Klein, PS
    Huang, HC
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (01) : 428 - 437
  • [95] MyoD meets its maker
    Rawls, A
    Olson, EN
    [J]. CELL, 1997, 89 (01) : 5 - 8
  • [96] Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a smad-binding antagonist of transforming growth factor-β signaling
    Rodriguez, C
    Huang, LJS
    Son, JK
    McKee, A
    Xiao, Z
    Lodish, HF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (32) : 30224 - 30230
  • [97] CLONING AND CHARACTERIZATION OF A HUMAN TYPE-II RECEPTOR FOR BONE MORPHOGENETIC PROTEINS
    ROSENZWEIG, BL
    IMAMURA, T
    OKADOME, T
    COX, GN
    YAMASHITA, H
    TENDIJKE, P
    HELDIN, CH
    MIYAZONO, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) : 7632 - 7636
  • [98] Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-β signaling, as a target of the β-catenin pathway in colorectal tumor cells
    Sekiya, T
    Adachi, S
    Kohu, K
    Yamada, T
    Higuchi, O
    Furukawa, Y
    Nakamura, Y
    Nakamura, T
    Tashiro, K
    Kuhara, S
    Ohwada, S
    Akiyama, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (08) : 6840 - 6846
  • [99] Negative regulation of bone morphogenetic protein/Smad signaling by cas-interacting zinc finger protein in osteoblasts
    Shen, ZJ
    Nakamoto, T
    Tsuji, K
    Nifuji, A
    Miyazono, K
    Komori, T
    Hirai, H
    Noda, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (33) : 29840 - 29846
  • [100] Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins
    Shi, W
    Chen, H
    Sun, JP
    Chen, C
    Zhao, JS
    Wang, YL
    Anderson, KD
    Warburton, D
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 286 (02) : L293 - L300