共 22 条
Plaque instability frequently occurs days or weeks before occlusive coronary thrombosis - A pathological thrombectomy study in primary percutaneous coronary intervention
被引:219
作者:

Rittersma, SZH
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h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

van der Wal, AC
论文数: 0 引用数: 0
h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

Koch, KT
论文数: 0 引用数: 0
h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

Piek, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

Henriques, JPS
论文数: 0 引用数: 0
h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

Mulder, KJ
论文数: 0 引用数: 0
h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

Ploegmakers, JPHM
论文数: 0 引用数: 0
h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

Meesterman, M
论文数: 0 引用数: 0
h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

de Winter, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands
机构:
[1] Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands
[2] Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands
关键词:
myocardial infarction;
thrombus;
occlusion;
D O I:
10.1161/01.CIR.0000157141.00778.AC
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background - Acute ST-elevation myocardial infarction (STEMI) is caused by sudden occlusive coronary thrombosis, after plaque disruption; however, a considerable time interval between plaque disturbance and the onset of symptoms has been suggested. We therefore studied the age of intracoronary thrombi, aspirated during angioplasty in patients with acute STEMI. Methods and Results - Percutaneous intracoronary thrombectomy during angioplasty was performed in 211 consecutive STEMI patients within 6 hours after onset of anginal symptoms. The aspirated material was histologically screened on thrombus and plaque components, and thrombus age was classified as fresh ( < 1 day), lytic thrombus ( 1 to 5 days), and organized thrombus ( > 5 days). In all patients, intracoronary-derived material was retrieved in the filter of the collection bottle. Thrombus was identified in 199 (95 %) of 211 patients. In 12 patients (5 %), only plaque components were identified, and in 85 patients (41 %), both thrombus and plaque material were aspirated. In 18 (9 %) of 199 patients, the thrombus was organized, and in 70 patients (35 %), the thrombus showed lytic changes, whereas in 98 (49 %), a completely fresh thrombus was found. In 14 (7 %) of 199 patients, the thrombus showed combined features of both fresh thrombus and organized thrombus. Conclusions - In at least 50 % of patients with acute STEMI, coronary thrombi were days or weeks old. This indicates that sudden coronary occlusion is often preceded by a variable period of plaque instability and thrombus formation, initiated days or weeks before onset of symptoms.
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页码:1160 / 1165
页数:6
相关论文
共 22 条
[11]
ABILITY OF THE NO-REFLOW PHENOMENON DURING AN ACUTE MYOCARDIAL-INFARCTION TO PREDICT LEFT-VENTRICULAR DYSFUNCTION AT ONE-MONTH FOLLOW-UP
[J].
KENNER, MD
;
ZAJAC, EJ
;
KONDOS, GT
;
DAVE, R
;
WINKELMANN, JW
;
JOFTUS, J
;
LAUCEVICIUS, A
;
KYBARSKIS, A
;
BERUKSTIS, E
;
URBONAS, A
;
FEINSTEIN, SB
.
AMERICAN JOURNAL OF CARDIOLOGY,
1995, 76 (12)
:861-868

KENNER, MD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

ZAJAC, EJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

KONDOS, GT
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

DAVE, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

WINKELMANN, JW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

JOFTUS, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

LAUCEVICIUS, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

KYBARSKIS, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

BERUKSTIS, E
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

URBONAS, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612

FEINSTEIN, SB
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ILLINOIS,CHICAGO,IL 60612
[12]
Prospective temporal analysis of the onset of preinfarction angina versus outcome - An ancillary study in TIMI-9B
[J].
Kloner, RA
;
Shook, T
;
Antman, EM
;
Cannon, CP
;
Przyklenk, K
;
Yoo, K
;
McCabe, CH
;
Braunwald, E
.
CIRCULATION,
1998, 97 (11)
:1042-1045

Kloner, RA
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Shook, T
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Antman, EM
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Cannon, CP
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Przyklenk, K
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Yoo, K
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

McCabe, CH
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA

Braunwald, E
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA
[13]
Intraplaque hemorrhage and progression of coronary atheroma
[J].
Kolodgie, FD
;
Gold, HK
;
Burke, AP
;
Fowler, DR
;
Kruth, HS
;
Weber, DK
;
Farb, A
;
Guerrero, LJ
;
Hayase, M
;
Kutys, R
;
Narula, J
;
Finn, AV
;
Virmani, R
.
NEW ENGLAND JOURNAL OF MEDICINE,
2003, 349 (24)
:2316-2325

Kolodgie, FD
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Gold, HK
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Burke, AP
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Fowler, DR
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Kruth, HS
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Weber, DK
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Farb, A
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Guerrero, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Hayase, M
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Kutys, R
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Narula, J
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Finn, AV
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA

Virmani, R
论文数: 0 引用数: 0
h-index: 0
机构: Armed Forces Inst Pathol, Dept Cardiovasc Pathol, Washington, DC 20306 USA
[14]
Plaque gruel of atheromatous coronary lesion may contribute to the no-reflow phenomenon in patients with acute coronary syndrome
[J].
Kotani, J
;
Nanto, S
;
Mintz, GS
;
Kitakaze, M
;
Ohara, T
;
Morozumi, T
;
Nagata, S
;
Hori, M
.
CIRCULATION,
2002, 106 (13)
:1672-1677

Kotani, J
论文数: 0 引用数: 0
h-index: 0
机构: Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6608511, Japan

Nanto, S
论文数: 0 引用数: 0
h-index: 0
机构: Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6608511, Japan

Mintz, GS
论文数: 0 引用数: 0
h-index: 0
机构: Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6608511, Japan

Kitakaze, M
论文数: 0 引用数: 0
h-index: 0
机构: Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6608511, Japan

Ohara, T
论文数: 0 引用数: 0
h-index: 0
机构: Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6608511, Japan

Morozumi, T
论文数: 0 引用数: 0
h-index: 0
机构: Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6608511, Japan

Nagata, S
论文数: 0 引用数: 0
h-index: 0
机构: Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6608511, Japan

Hori, M
论文数: 0 引用数: 0
h-index: 0
机构: Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6608511, Japan
[15]
Abortion of acute ST segment elevation myocardial infarction after reperfusion: incidence, patients' characteristics, and prognosis
[J].
Lamfers, EJP
;
Hooghoudt, TEH
;
Hertzberger, DP
;
Schut, A
;
Stolwijk, PWJ
;
Verheugt, FWA
.
HEART,
2003, 89 (05)
:496-501

Lamfers, EJP
论文数: 0 引用数: 0
h-index: 0
机构: Canisius Wilhelmina Hosp, Dept Cardiol, NL-6500 GS Nijmegen, Netherlands

Hooghoudt, TEH
论文数: 0 引用数: 0
h-index: 0
机构: Canisius Wilhelmina Hosp, Dept Cardiol, NL-6500 GS Nijmegen, Netherlands

Hertzberger, DP
论文数: 0 引用数: 0
h-index: 0
机构: Canisius Wilhelmina Hosp, Dept Cardiol, NL-6500 GS Nijmegen, Netherlands

Schut, A
论文数: 0 引用数: 0
h-index: 0
机构: Canisius Wilhelmina Hosp, Dept Cardiol, NL-6500 GS Nijmegen, Netherlands

Stolwijk, PWJ
论文数: 0 引用数: 0
h-index: 0
机构: Canisius Wilhelmina Hosp, Dept Cardiol, NL-6500 GS Nijmegen, Netherlands

Verheugt, FWA
论文数: 0 引用数: 0
h-index: 0
机构: Canisius Wilhelmina Hosp, Dept Cardiol, NL-6500 GS Nijmegen, Netherlands
[16]
Rapid thrombectomy for treatment of macroembolization during percutaneous coronary intervention in the setting of acute myocardial infarction
[J].
Lorin, JD
;
Liou, MC
;
Sedlis, SP
.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS,
2003, 59 (02)
:219-222

Lorin, JD
论文数: 0 引用数: 0
h-index: 0
机构: Dept Vet Affairs, New York Harbor Healthcare Syst, Div Cardiol, New York, NY USA

Liou, MC
论文数: 0 引用数: 0
h-index: 0
机构: Dept Vet Affairs, New York Harbor Healthcare Syst, Div Cardiol, New York, NY USA

Sedlis, SP
论文数: 0 引用数: 0
h-index: 0
机构: Dept Vet Affairs, New York Harbor Healthcare Syst, Div Cardiol, New York, NY USA
[17]
Mechanisms of progression in native coronary artery disease: role of healed plaque disruption
[J].
Mann, J
;
Davies, MJ
.
HEART,
1999, 82 (03)
:265-268

Mann, J
论文数: 0 引用数: 0
h-index: 0
机构:
St George Hosp, Sch Med, British Heart Fdn, Cardiovasc Pathol Unit, London SW17 0RE, England St George Hosp, Sch Med, British Heart Fdn, Cardiovasc Pathol Unit, London SW17 0RE, England

Davies, MJ
论文数: 0 引用数: 0
h-index: 0
机构:
St George Hosp, Sch Med, British Heart Fdn, Cardiovasc Pathol Unit, London SW17 0RE, England St George Hosp, Sch Med, British Heart Fdn, Cardiovasc Pathol Unit, London SW17 0RE, England
[18]
Intracoronary aspiration thrombectomy for acute myocardial infarction
[J].
Murakami, T
;
Mizuno, S
;
Takahashi, Y
;
Ohsato, K
;
Moriuchi, I
;
Arai, Y
;
Mifune, J
;
Shimizu, M
;
Ohnaka, M
.
AMERICAN JOURNAL OF CARDIOLOGY,
1998, 82 (07)
:839-844

Murakami, T
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan

Mizuno, S
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan

Takahashi, Y
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan

Ohsato, K
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan

Moriuchi, I
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan

Arai, Y
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan

Mifune, J
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan

Shimizu, M
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan

Ohnaka, M
论文数: 0 引用数: 0
h-index: 0
机构: Fukui Cardiovasc Ctr, Dept Cardiol, Fukui 9100833, Japan
[19]
Characteristics of the pathological images of coronary artery thrombi according to the infarct-related coronary artery in acute myocardial infarction
[J].
Nagata, Y
;
Usuda, K
;
Uchiyama, A
;
Uchikoshi, M
;
Sekiguchi, Y
;
Kato, H
;
Miwa, A
;
Ishikawa, T
.
CIRCULATION JOURNAL,
2004, 68 (04)
:308-314

Nagata, Y
论文数: 0 引用数: 0
h-index: 0
机构: Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama 9308550, Japan

Usuda, K
论文数: 0 引用数: 0
h-index: 0
机构: Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama 9308550, Japan

Uchiyama, A
论文数: 0 引用数: 0
h-index: 0
机构: Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama 9308550, Japan

Uchikoshi, M
论文数: 0 引用数: 0
h-index: 0
机构: Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama 9308550, Japan

Sekiguchi, Y
论文数: 0 引用数: 0
h-index: 0
机构: Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama 9308550, Japan

Kato, H
论文数: 0 引用数: 0
h-index: 0
机构: Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama 9308550, Japan

Miwa, A
论文数: 0 引用数: 0
h-index: 0
机构: Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama 9308550, Japan

Ishikawa, T
论文数: 0 引用数: 0
h-index: 0
机构: Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama 9308550, Japan
[20]
Considerable time from the onset of plaque rupture and/or thrombi until the onset of acute myocardial infarction in humans - Coronary angiographic findings within 1 week before the onset of infarction
[J].
Ojio, S
;
Takatsu, H
;
Tanaka, T
;
Ueno, K
;
Yokoya, K
;
Matsubara, T
;
Suzuki, T
;
Watanabe, S
;
Morita, N
;
Kawasaki, M
;
Nagano, T
;
Nishio, I
;
Sakai, K
;
Nishigaki, K
;
Takemura, G
;
Noda, T
;
Minatoguchi, S
;
Fujiwara, H
.
CIRCULATION,
2000, 102 (17)
:2063-2069

Ojio, S
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Takatsu, H
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Tanaka, T
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Ueno, K
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Yokoya, K
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Matsubara, T
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Suzuki, T
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Watanabe, S
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Morita, N
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Kawasaki, M
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Nagano, T
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Nishio, I
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Sakai, K
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Nishigaki, K
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Takemura, G
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Noda, T
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Minatoguchi, S
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan

Fujiwara, H
论文数: 0 引用数: 0
h-index: 0
机构: Gifu Univ, Sch Med, Dept Internal Med 2, MUGIC Grp,Multictr Study, Gifu 500, Japan