Use of QSARs in international decision-making frameworks to predict health effects of chemical substances

被引:180
作者
Cronin, MTD
Jaworska, JS
Walker, JD
Comber, MHI
Watts, CD
Worth, AP
机构
[1] Liverpool John Moores Univ, Sch Pharm & Chem, Liverpool L3 3AF, Merseyside, England
[2] Procter & Gamble, Eurocor, Strombeek Bever, Belgium
[3] US EPA, TSCA Interagcy, Testing Comm, Washington, DC 20460 USA
[4] ExxonMobil Biomed Sci Inc, Prod Stewardship & Regulatory Affairs, Machelen, Belgium
[5] NSF, WRc, Natl Ctr Environm Toxicol, Marlow, Bucks, England
[6] European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, European Chem Bur, Ispra, Italy
关键词
chemical substances; human health effects; prediction; QSAR; regulatory agencies; toxicity;
D O I
10.1289/ehp.5760
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.
引用
收藏
页码:1391 / 1401
页数:11
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