Use of QSARs in international decision-making frameworks to predict health effects of chemical substances

被引：180

作者：

Cronin, MTD

Jaworska, JS

Walker, JD

Comber, MHI

Watts, CD

Worth, AP

机构：

[1] Liverpool John Moores Univ, Sch Pharm & Chem, Liverpool L3 3AF, Merseyside, England

[2] Procter & Gamble, Eurocor, Strombeek Bever, Belgium

[3] US EPA, TSCA Interagcy, Testing Comm, Washington, DC 20460 USA

[4] ExxonMobil Biomed Sci Inc, Prod Stewardship & Regulatory Affairs, Machelen, Belgium

[5] NSF, WRc, Natl Ctr Environm Toxicol, Marlow, Bucks, England

[6] European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, European Chem Bur, Ispra, Italy

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2003年 / 111卷 / 10期

关键词：

chemical substances; human health effects; prediction; QSAR; regulatory agencies; toxicity;

D O I：

10.1289/ehp.5760

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.

引用

页码：1391 / 1401

页数：11

共 86 条

[1] Draize eye scores and eye irritation thresholds in man combined into one quantitative structure-activity relationship [J].