Poly(ADP-ribose) -: The most elaborate metabolite of NAD

被引：237

作者：

Bürkle, A ^{[1
]}

机构：

[1] Univ Konstanz, Dept Biol, D-78457 Constance, Germany

来源：

FEBS JOURNAL | 2005年 / 272卷 / 18期

关键词：

PARP; tankyrase; poly(ADP-ribose); DNA damage; DNA repair; genomic instability; centrosome; centromere; telomeres; mitotic spindle;

D O I：

10.1111/j.1742-4658.2005.04864.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the most drastic post-translational modification of proteins in eukaryotic cells is poly(ADP-ribosyl)ation, catalysed by a family enzymes termed poly(ADP-ribose) polymerases (PARPs). In the human genome, 18 different genes have been identified that all encode PARP family members. Poly(ADP-ribose) metabolism plays a role in a wide range of biological structures and processes, including DNA repair and maintenance of genomic stability, transcriptional regulation, centromere function and mitotic spindle formation, centrosomal function, structure and function of vault particles, telomere dynamics, trafficking of endosomal vesicles, apoptosis and necrosis. In this article, the most recent advances in this rapidly growing field are summarized.

引用

页码：4576 / 4589

页数：14

共 112 条

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